Iridium-Catalyzed Asymmetric Hydrogenation of Quinoline Derivatives with C3*-TunePhos

被引：56

作者：

Gou, Fa-Rong ^{[1
,2
]}

Li, Wei ^{[1
,3
]}

Zhang, Xumu ^{[1
]}

Liang, Yong-Min ^{[2
]}

机构：

[1] Rutgers State Univ, Dept Med Chem, Piscataway, NJ 08854 USA

[2] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

[3] Penn State Univ, Dept Chem, University Pk, PA 16802 USA

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2010年 / 352卷 / 14-15期

基金：

美国国家卫生研究院;

关键词：

asymmetric catalysis; enantioselectivity; hydrogenation; iridium; quinolines; HIGHLY ENANTIOSELECTIVE HYDROGENATION; CHIRAL DIPHOSPHINE LIGANDS; BISPHOSPHINE LIGANDS; EFFICIENT; COMPLEXES; VERSATILE; ENHANCEMENT;

D O I：

10.1002/adsc.201000485

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A series of C-3*-TunePhos chiral diphosphine ligands has been successfully applied in the iridium-catalyzed enantioselective hydrogenation of quinolines, and this methodology provided an efficient access to a variety of optically active tetrahydroquinolines with up to 93% ee. Furthermore, attempts on the asymmetric hydrogenation of quinoline N-oxide are also discussed.

引用

页码：2441 / 2444

页数：4

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