Molecular Management of Multifocal Atrial Tachycardia in Noonan's Syndrome With MEK1/2 Inhibitor Trametinib

被引:17
作者
Meisner, Joshua K. [1 ]
Bradley, David J. [1 ]
Russell, Mark W. [1 ]
机构
[1] Univ Michigan, Div Pediat Cardiol, Ann Arbor, MI 48109 USA
来源
CIRCULATION-GENOMIC AND PRECISION MEDICINE | 2021年 / 14卷 / 05期
关键词
cardiac arrhythmia; cardiomyopathy; hypertrophic; molecular targeted therapy; Noonan Syndrome; raf-1; Kinase; HYPERTROPHIC CARDIOMYOPATHY;
D O I
10.1161/CIRCGEN.121.003327
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页数:3
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共 6 条
  • [1] Hypertrophic Cardiomyopathy in Noonan Syndrome Treated by MEK-Inhibition
    Andelfinger, Gregor
    Marquis, Christopher
    Raboisson, Marie-Josee
    Theoret, Yves
    Waldmuller, Stephan
    Wiegand, Gesa
    Gelb, Bruce D.
    Zenker, Martin
    Delrue, Marie-Ange
    Hofbeck, Michael
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2019, 73 (17) : 2237 - +
  • [2] Crosstalk between PKC and MAPK pathway activation in cardiac fibroblasts in a rat model of atrial fibrillation
    Guo, Wei-hua
    Wang, Xian
    Shang, Mei-sheng
    Chen, Zhe
    Guo, Qi
    Li, Li
    Wang, Hai-ying
    Yu, Rong-hui
    Ma, Chang-sheng
    [J]. BIOTECHNOLOGY LETTERS, 2020, 42 (07) : 1219 - 1227
  • [3] Inducible Pluripotent Stem Cell-Derived Cardiomyocytes Reveal Aberrant Extracellular Regulated Kinase 5 and Mitogen-Activated Protein Kinase Kinase 1/2 Signaling Concomitantly Promote Hypertrophic Cardiomyopathy in RAF1-Associated Noonan Syndrome
    Jaffre, Fabrice
    Miller, Clint L.
    Schaenzer, Anne
    Evans, Todd
    Roberts, Amy E.
    Hahn, Andreas
    Kontaridis, Maria I.
    [J]. CIRCULATION, 2019, 140 (03) : 207 - 224
  • [4] Nonreentrant atrial tachycardia occurs independently of hypertrophic cardiomyopathy in RASopathy patients
    Levin, Mark D.
    Saitta, Sulagna C.
    Gripp, Karen W.
    Wenger, Tara L.
    Ganesh, Jaya
    Kalish, Jennifer M.
    Epstein, Michael R.
    Smith, Rosemarie
    Czosek, Richard J.
    Ware, Stephanie M.
    Goldenberg, Paula
    Myers, Angela
    Chatfield, Kathryn C.
    Gillespie, Matthew J.
    Zackai, Elaine H.
    Lin, Angela E.
    [J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2018, 176 (08) : 1711 - 1722
  • [5] Inhibition of cAMP-Dependent PKA Activates β2-Adrenergic Receptor Stimulation of Cytosolic Phospholipase A2 via Raf-1/MEK/ERK and IP3-Dependent Ca2+ Signaling in Atrial Myocytes
    Pabbidi, M. R.
    Ji, X.
    Maxwell, J. T.
    Mignery, G. A.
    Samarel, A. M.
    Lipsius, S. L.
    [J]. PLOS ONE, 2016, 11 (12):
  • [6] Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy
    Pandit, Bhaswati
    Sarkozy, Anna
    Pennacchio, Len A.
    Carta, Claudio
    Oishi, Kimihiko
    Martinelli, Simone
    Pogna, Edgar A.
    Schackwitz, Wendy
    Ustaszewska, Anna
    Landstrom, Andrew
    Bos, J. Martijn
    Ommen, Steve R.
    Esposito, Giorgia
    Lepri, Francesca
    Faul, Christian
    Mundel, Peter
    Siguero, Juan P. Lopez
    Tenconi, Romano
    Selicorni, Angelo
    Rossi, Cesare
    Mazzanti, Laura
    Torrente, Isabella
    Marino, Bruno
    Digilio, Maria C.
    Zampino, Giuseppe
    Ackerman, Michael J.
    Dallapiccola, Bruno
    Tartaglia, Marco
    Gelb, Bruce D.
    [J]. NATURE GENETICS, 2007, 39 (08) : 1007 - 1012