Molecular Management of Multifocal Atrial Tachycardia in Noonan's Syndrome With MEK1/2 Inhibitor Trametinib

被引：21

作者：

Meisner, Joshua K. ^{[1
]}

Bradley, David J. ^{[1
]}

Russell, Mark W. ^{[1
]}

机构：

[1] Univ Michigan, Div Pediat Cardiol, Ann Arbor, MI 48109 USA

来源：

CIRCULATION-GENOMIC AND PRECISION MEDICINE | 2021年 / 14卷 / 05期

关键词：

cardiac arrhythmia; cardiomyopathy; hypertrophic; molecular targeted therapy; Noonan Syndrome; raf-1; Kinase; HYPERTROPHIC CARDIOMYOPATHY;

D O I：

10.1161/CIRCGEN.121.003327

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

[No abstract available]

引用

页数：3

共 6 条

[1] Hypertrophic Cardiomyopathy in Noonan Syndrome Treated by MEK-Inhibition [J].

Andelfinger, Gregor ;

Marquis, Christopher ;

Raboisson, Marie-Josee ;

Theoret, Yves ;

Waldmuller, Stephan ;

Wiegand, Gesa ;

Gelb, Bruce D. ;

Zenker, Martin ;

Delrue, Marie-Ange ;

Hofbeck, Michael .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2019, 73 (17) :2237-+

[2] Crosstalk between PKC and MAPK pathway activation in cardiac fibroblasts in a rat model of atrial fibrillation [J].

Guo, Wei-hua ;

Wang, Xian ;

Shang, Mei-sheng ;

Chen, Zhe ;

Guo, Qi ;

Li, Li ;

Wang, Hai-ying ;

Yu, Rong-hui ;

Ma, Chang-sheng .

BIOTECHNOLOGY LETTERS, 2020, 42 (07) :1219-1227

[3] Inducible Pluripotent Stem Cell-Derived Cardiomyocytes Reveal Aberrant Extracellular Regulated Kinase 5 and Mitogen-Activated Protein Kinase Kinase 1/2 Signaling Concomitantly Promote Hypertrophic Cardiomyopathy in RAF1-Associated Noonan Syndrome [J].

Jaffre, Fabrice ;

Miller, Clint L. ;

Schaenzer, Anne ;

Evans, Todd ;

Roberts, Amy E. ;

Hahn, Andreas ;

Kontaridis, Maria I. .

CIRCULATION, 2019, 140 (03) :207-224

[4] Nonreentrant atrial tachycardia occurs independently of hypertrophic cardiomyopathy in RASopathy patients [J].

Levin, Mark D. ;

Saitta, Sulagna C. ;

Gripp, Karen W. ;

Wenger, Tara L. ;

Ganesh, Jaya ;

Kalish, Jennifer M. ;

Epstein, Michael R. ;

Smith, Rosemarie ;

Czosek, Richard J. ;

Ware, Stephanie M. ;

Goldenberg, Paula ;

Myers, Angela ;

Chatfield, Kathryn C. ;

Gillespie, Matthew J. ;

Zackai, Elaine H. ;

Lin, Angela E. .

AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2018, 176 (08) :1711-1722

[5] Inhibition of cAMP-Dependent PKA Activates β2-Adrenergic Receptor Stimulation of Cytosolic Phospholipase A2 via Raf-1/MEK/ERK and IP3-Dependent Ca2+ Signaling in Atrial Myocytes [J].

Pabbidi, M. R. ;

Ji, X. ;

Maxwell, J. T. ;

Mignery, G. A. ;

Samarel, A. M. ;

Lipsius, S. L. .

PLOS ONE, 2016, 11 (12)

[6] Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy [J].

Pandit, Bhaswati ;

Sarkozy, Anna ;

Pennacchio, Len A. ;

Carta, Claudio ;

Oishi, Kimihiko ;

Martinelli, Simone ;

Pogna, Edgar A. ;

Schackwitz, Wendy ;

Ustaszewska, Anna ;

Landstrom, Andrew ;

Bos, J. Martijn ;

Ommen, Steve R. ;

Esposito, Giorgia ;

Lepri, Francesca ;

Faul, Christian ;

Mundel, Peter ;

Siguero, Juan P. Lopez ;

Tenconi, Romano ;

Selicorni, Angelo ;

Rossi, Cesare ;

Mazzanti, Laura ;

Torrente, Isabella ;

Marino, Bruno ;

Digilio, Maria C. ;

Zampino, Giuseppe ;

Ackerman, Michael J. ;

Dallapiccola, Bruno ;

Tartaglia, Marco ;

Gelb, Bruce D. .

NATURE GENETICS, 2007, 39 (08) :1007-1012

← 1 →