Copper(II) chloride catalyzed Friedel-Crafts-type conjugate addition of indoles to α,β-unsaturated enones: Synthesis of 3-substituted indoles

被引：0

作者：

Kanwar, Deepika ^{[1
]}

Rani, Rashmi ^{[1
]}

Agarwal, Jyoti ^{[1
]}

Peddinti, Rama Krishna ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Roorkee 247667, Uttar Pradesh, India

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2010年 / 49卷 / 09期

关键词：

Conjugate addition; copper(II) chloride; indole derivatives; chalcones; beta-indoloylketones; MICHAEL ADDITION; BETA-INDOLYLKETONES; EFFICIENT; KETONES; ALKYLATION; PYRROLE; ALPHA;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several 3-substituted indoles have been synthesized in good to excellent yields by conjugate addition of indoles to alpha,beta-unsaturated enones such as chalcones. methyl vinyl ketone and cyclohexenone in the presence of catalytic amount of copper(11) chloride. The substitution of indoles occurred exclusively at the 3-position. and products of N-alkylation have not been observed.

引用

页码：1290 / 1299

页数：10

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