Copper-catalyzed regioselective 1,4-sulfonylcyanation of 1,3-enynes with sulfonyl chlorides and TMSCN

被引：21

作者：

Lv, Yunhe ^{[1
]}

Han, Wanru ^{[1
]}

Pu, Weiya ^{[1
]}

Xie, Jinhui ^{[1
]}

Wang, Axue ^{[1
]}

Zhang, Mengyue ^{[1
]}

Wang, Jin ^{[1
]}

Lai, Junrong ^{[1
]}

机构：

[1] Anyang Normal Univ, Coll Chem & Chem Engn, Anyang 455000, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2022年 / 9卷 / 14期

基金：

中国国家自然科学基金;

关键词：

ALKYNES; AMINODIFLUOROALKYLATION; FUNCTIONALIZATION; ALKENES;

D O I：

10.1039/d2qo00486k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel and practical copper-catalyzed reaction for the 1,4-sulfonylcyanation of 1,3-enynes under mild conditions is described. This protocol provides efficient and straightforward access to a variety of 5-sulfonylpenta-2,3-dienenitrile derivatives with excellent functional group tolerance and good regioselectivity from readily available 1,3-enynes and commercially available sulfonyl chlorides and TMSCN. A mechanism involving sulfonyl and allenyl radical species is proposed.

引用

页码：3775 / 3780

页数：6

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