A highly active palladium catalyst system for the arylation of anilines

被引:113
作者
Sadighi, JP [1 ]
Harris, MC [1 ]
Buchwald, SL [1 ]
机构
[1] MIT, Dept Chem, Cambridge, MA 02139 USA
基金
美国国家科学基金会;
关键词
D O I
10.1016/S0040-4039(98)00988-5
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The chelating ligand bis[2-(diphenylphosphino)phenyl] ether (DPEphos), in combination with palladium acetate, forms a highly active catalyst system for the coupling of anilines with aryl bromides. The bisphosphine is easily prepared in large quantity and at low cost by a known procedure. The catalyst system is effective in coupling reactions involving a variety of substrates, including electron-poor anilines or electron-rich aryl bromides. In addition, it tolerates a high degree of steric congestion at both the aniline and the aryl bromide. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
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页码:5327 / 5330
页数:4
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