A highly active palladium catalyst system for the arylation of anilines

被引：114

作者：

Sadighi, JP ^{[1
]}

Harris, MC ^{[1
]}

Buchwald, SL ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 30期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0040-4039(98)00988-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The chelating ligand bis[2-(diphenylphosphino)phenyl] ether (DPEphos), in combination with palladium acetate, forms a highly active catalyst system for the coupling of anilines with aryl bromides. The bisphosphine is easily prepared in large quantity and at low cost by a known procedure. The catalyst system is effective in coupling reactions involving a variety of substrates, including electron-poor anilines or electron-rich aryl bromides. In addition, it tolerates a high degree of steric congestion at both the aniline and the aryl bromide. (C) 1998 Elsevier Science Ltd. All rights reserved.

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收藏

页码：5327 / 5330

页数：4

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