Allergenic Properties and Molecular Characteristics of PR-1 Proteins

被引：10

作者：

Wangorsch, Andrea ^{[1
]}

Scheurer, Stephan ^{[1
]}

Blanca, Miguel ^{[2
]}

Blanca-Lopez, Natalia ^{[3
]}

Somoza, Maria Luisa ^{[3
]}

Martin-Pedraza, Laura ^{[2
]}

机构：

[1] Paul Ehrlich Inst, Mol Allergol, Langen, Germany

[2] Hosp Univ Infanta Leonor, Fdn Biomed Res & Innovat, Madrid, Spain

[3] Hosp Univ Infanta Leonor, Allergy Serv, Madrid, Spain

来源：

FRONTIERS IN ALLERGY | 2022年 / 3卷

关键词：

pathogenesis-related protein-1; PR-1; allergen; occupational allergy; allergy diagnosis; PATHOGENESIS-RELATED PROTEINS; ANTIGENIC CROSS-REACTIVITY; VENOM ALLERGEN; STRUCTURAL-ANALYSIS; OCCUPATIONAL ASTHMA; HYMENOPTERA VENOM; MUGWORT POLLEN; TREE POLLEN; IDENTIFICATION; PEACH;

D O I：

10.3389/falgy.2022.824717

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Only a small fraction of proteins in plants and animals are classified as allergens. The allergenic properties are frequently attributed to certain functional characteristics of the proteins, such as a role in the plant defense against biotic and abiotic stress, to achieve the systematic acquired resistance. In line with this, eight members out of 17 functional pathogenesis-related (PR) protein families have been characterized as allergens. The present review summarizes the molecular features and allergenic significance of allergens of the PR-1 family. Not many allergens have been identified as belonging to this protein family, with most of them having a pollen origin, like mugwort or Bermuda grass. Molecular and structural features of allergenic PR-1 proteins are discussed and attributed to their IgE-reactive properties, clinical manifestation, and cross-reactivity among different foods and inhalants.

引用

页数：8

共 68 条

[11] Platyhelminth Venom Allergen-Like (VAL) proteins: revealing structural diversity, class-specific features and biological associations across the phylum [J].