Allergenic Properties and Molecular Characteristics of PR-1 Proteins

被引：10
作者：
Wangorsch, Andrea [1 ]
Scheurer, Stephan [1 ]
Blanca, Miguel [2 ]
Blanca-Lopez, Natalia [3 ]
Somoza, Maria Luisa [3 ]
Martin-Pedraza, Laura [2 ]
机构：
[1] Paul Ehrlich Inst, Mol Allergol, Langen, Germany
[2] Hosp Univ Infanta Leonor, Fdn Biomed Res & Innovat, Madrid, Spain
[3] Hosp Univ Infanta Leonor, Allergy Serv, Madrid, Spain
来源：
FRONTIERS IN ALLERGY | 2022年 / 3卷
关键词：
pathogenesis-related protein-1; PR-1; allergen; occupational allergy; allergy diagnosis; PATHOGENESIS-RELATED PROTEINS; ANTIGENIC CROSS-REACTIVITY; VENOM ALLERGEN; STRUCTURAL-ANALYSIS; OCCUPATIONAL ASTHMA; HYMENOPTERA VENOM; MUGWORT POLLEN; TREE POLLEN; IDENTIFICATION; PEACH;
D O I：
10.3389/falgy.2022.824717
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Only a small fraction of proteins in plants and animals are classified as allergens. The allergenic properties are frequently attributed to certain functional characteristics of the proteins, such as a role in the plant defense against biotic and abiotic stress, to achieve the systematic acquired resistance. In line with this, eight members out of 17 functional pathogenesis-related (PR) protein families have been characterized as allergens. The present review summarizes the molecular features and allergenic significance of allergens of the PR-1 family. Not many allergens have been identified as belonging to this protein family, with most of them having a pollen origin, like mugwort or Bermuda grass. Molecular and structural features of allergenic PR-1 proteins are discussed and attributed to their IgE-reactive properties, clinical manifestation, and cross-reactivity among different foods and inhalants.
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页数：8
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