One-Pot, Three-Component Arylalkynyl Sulfone Synthesis

被引：120
作者：
Chen, C. Chun [1 ]
Waser, Jerome [1 ]
机构：
[1] Ecole Polytech Fed Lausanne, Lab Catalysis & Organ Synth, EPFL SB ISIC LCSO, CH-1015 Lausanne, Switzerland
来源：
ORGANIC LETTERS | 2015年 / 17卷 / 03期
基金：
欧洲研究理事会;
关键词：
HYPERVALENT IODINE REAGENTS; SULFUR-DIOXIDE; ALKYNYLATING REAGENTS; ALKYNYLIODONIUM SALTS; CATALYZED SYNTHESIS; EBX; ARYLSULFONYLACETYLENES; ETHYNYLATION; HETEROCYCLES; CHEMISTRY;
D O I：
10.1021/acs.orglett.5b00015
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A one-pot three-component protocol for the preparation of arylsulfonyl alkynes through the reaction of ethynyl-benziodoxolone (EBX) reagents, DABSO (DABCO.SO2), and either organomagnesium reagents or aryl iodides with a palladium catalyst is reported. A broad range of aryl and heteroarylalkynyl sulfones were obtained in 46-85% overall yield.
引用
收藏
页码：736 / 739
页数：4
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