Determination of salivary uric acid by using poly(3,4-ethylenedioxythipohene) and graphene oxide in a disposable paper-based analytical device

被引：46

作者：

Huang, Xin ^{[1
]}

Shi, Weishan ^{[1
]}

Li, Jing ^{[1
]}

Bao, Ning ^{[1
]}

Yu, Chunmei ^{[1
]}

Gu, Haiying ^{[1
]}

机构：

[1] Nantong Univ, Sch Publ Hlth, Nantong 226019, Peoples R China

来源：

ANALYTICA CHIMICA ACTA | 2020年 / 1103卷

基金：

中国国家自然科学基金;

关键词：

Uric acid; Poly (3,4-ethylenedioxythipohene); Graphene oxide; Paper-based analytical device; Human saliva; GLASSY-CARBON ELECTRODE; ASCORBIC-ACID; ELECTROCHEMICAL DETECTION; CONDUCTING POLYMER; CAPILLARY-ELECTROPHORESIS; POTENTIAL APPLICATION; FAST DIAGNOSIS; DOPAMINE; COMPOSITE; BIOSENSOR;

D O I：

10.1016/j.aca.2019.12.057

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We developed a paper-based analytical device based on the electropolymerization of poly (3,4-ethylenedioxythipohene) (PEDOT) and graphene oxide (GO) composites on the ITO substrate for the detection of uric acid (UA) in authentic human saliva. Scanning electron microscopy, UV-vis spectrum and X-ray diffraction confirmed the formation of porous PEDOT combined with GO film during the electropolymerization process. The nanocomposite based sensor showed an enhanced electrocatalytic activity toward UA with high sensitivity and stability. We demonstrate that UA can be directly detected in undiluted saliva using the paper-based electroanalytical device with no interference from ascorbic acid and dopamine that are normally present in biological fluids. The results indicated that the developed device is promising for non-invasive monitoring of salivary UA in human body. (c) 2019 Elsevier B.V. All rights reserved.

引用

页码：75 / 83

页数：9

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