Advances in organ-on-a-chip systems for modelling joint tissue and osteoarthritic diseases

被引:36
作者
Banh, L. [1 ,2 ,3 ]
Cheung, K. K. [4 ]
Chan, M. W. Y. [1 ,2 ,3 ]
Young, E. W. K. [3 ,4 ,6 ]
Viswanathan, S. [1 ,2 ,3 ,5 ,7 ]
机构
[1] Univ Hlth Network, Schroeder Arthrit Inst, Osteoarthritis Res Program, Div Orthoped Surg, Toronto, ON, Canada
[2] Univ Hlth Network, Krembil Res Inst, Toronto, ON, Canada
[3] Univ Toronto, Inst Biomed Engn, Toronto, ON, Canada
[4] Univ Toronto, Dept Mech & Ind Engn, Toronto, ON, Canada
[5] Univ Toronto, Dept Med, Div Hematol, Toronto, ON, Canada
[6] 5 Kings Coll Rd,MC313, Toronto, ON M5S 3G8, Canada
[7] 60 Leonard Ave, Toronto, ON M5T 0S8, Canada
关键词
Osteoarthritis; Organ-on-a-chip; Tissue engineering; In vitro models; Microfluidics; HIGH-THROUGHPUT; KNEE MENISCUS; SHEAR-STRESS; RISK-FACTORS; MICROFLUIDICS; CHONDROCYTES;
D O I
10.1016/j.joca.2022.03.012
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Joint-on-a-chip (JOC) models are powerful tools that aid in osteoarthritis (OA) research. These micro -fluidic devices apply emerging organ-on-a-chip technology to recapitulate a multifaceted joint tissue microenvironment. JOCs address the need for advanced, dynamic in vitro models that can mimic the in vivo tissue environment through joint-relevant biomechanical or fluidic integration, an aspect that existing in vitro OA models lack. There are existing review articles on OA models that focus on animal, tissue explant, and two-dimensional and three-dimensional (3D) culture systems, including micro-bioreactors and 3D printing technology, but there has been limited discussion of JOC models. The aim of this article is to review recent developments in human JOC technology and identify gaps for future advancements. Specifically, mechanical stimulation systems that mimic articular movement, multi-joint tissue cultures that enable crosstalk, and systems that aim to capture aspects of OA inflammation by incorporating immune cells are covered. The development of an advanced JOC model that captures the dynamic joint microenvironment will improve testing and translation of potential OA therapeutics.(c) 2022 The Author(s). Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International. This is an open access article under the CC BY license (http://creativecommons.org/ licenses/by/4.0/).
引用
收藏
页码:1050 / 1061
页数:12
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