Izumiphenazines A-C: Isolation and Structure Elucidation of Phenazine Derivatives from Streptomyces sp. IFM 11204

被引：67

作者：

Abdelfattah, Mohamed S. ^{[1
,2
]}

Kazufumi, Toume ^{[1
]}

Ishibashi, Masami ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Pharmaceut Sci, Inage Ku, Chiba 2638522, Japan

[2] Helwan Univ, Fac Sci, Dept Chem, Cairo 11795, Egypt

来源：

JOURNAL OF NATURAL PRODUCTS | 2010年 / 73卷 / 12期

基金：

日本学术振兴会;

关键词：

CONTAINING NATURAL-PRODUCTS; KITASATOSPORA SP IFM10917; CELL PROTECTING ACTIVITY; UP-REGULATION; TUMOR-CELLS; TRAIL; APOPTOSIS; ANTIBIOTICS; CANCER; BIOSYNTHESIS;

D O I：

10.1021/np100400t

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new phenazine derivatives, named izumiphenazines A-C (1-3), and the known phenazine-1,6-dicarboxylic acid (4) were isolated from Streptomyces sp. IFM 11204. The structures of the isolated compounds were elucidated by means of spectroscopic methods including UV, IR, HRESIMS, and ID and 2D NMR. Compounds 1-3 were evaluated for their activity in overcoming TRAIL (TNF-related apoptosis-inducing ligand) resistance in human gastric adenocarcinoma cells. Compounds 2 (30 mu M) and 3 (20 mu M) in combination with TRAIL showed synergistic activity in sensitizing TRAIL-resistant AGS cells.

引用

收藏

页码：1999 / 2002

页数：4

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