nuclear magnetic relaxation;
protein dynamics;
N-15 relaxation in proteins;
model-free approach;
spectral density mapping;
D O I:
暂无
中图分类号:
O63 [高分子化学(高聚物)];
学科分类号:
070305 ;
080501 ;
081704 ;
摘要:
In the review (63 references) the nuclear magnetic relaxation which is a unique experimental method giving insight into dynamic processes existing in proteins and covering a broad range of time scales was presented. This method, however, is demanding experimentally and theoretically. Exprimental methods limited to N-15 nuclei are briefly presented and their limitations discussed. Analysis of experimental relaxation data for proteins can be done in the frame of model-free approach or applying spectral density mapping. Both those approaches are difficult for the physical interpretation of results. Besides motional parameters, some structural parameters influence relaxation rates and have to be estimated or determined. Hopefully, many problems connected with the analysis of relaxation data in proteins can be overcome with relaxation measurements at multiple magnetic fields for different isotopes like N-15,C-13, and H-2.
机构:
Ecole Super Biotechnol Strasbourg, CNRS, UMR 7104, F-67412 Illkirch Graffenstaden, FranceEcole Super Biotechnol Strasbourg, CNRS, UMR 7104, F-67412 Illkirch Graffenstaden, France
Atkinson, RA
Kieffer, B
论文数: 0引用数: 0
h-index: 0
机构:
Ecole Super Biotechnol Strasbourg, CNRS, UMR 7104, F-67412 Illkirch Graffenstaden, FranceEcole Super Biotechnol Strasbourg, CNRS, UMR 7104, F-67412 Illkirch Graffenstaden, France
机构:Laboratory of Chemical Physics, Building 2 National Institute of Diabetes, Digestive and Kidney Diseases National Institutes of Health, Maryland, 20892, Bethesda
CLORE, GM
SZABO, A
论文数: 0引用数: 0
h-index: 0
机构:Laboratory of Chemical Physics, Building 2 National Institute of Diabetes, Digestive and Kidney Diseases National Institutes of Health, Maryland, 20892, Bethesda
SZABO, A
BAX, A
论文数: 0引用数: 0
h-index: 0
机构:Laboratory of Chemical Physics, Building 2 National Institute of Diabetes, Digestive and Kidney Diseases National Institutes of Health, Maryland, 20892, Bethesda
BAX, A
KAY, LE
论文数: 0引用数: 0
h-index: 0
机构:Laboratory of Chemical Physics, Building 2 National Institute of Diabetes, Digestive and Kidney Diseases National Institutes of Health, Maryland, 20892, Bethesda
KAY, LE
DRISCOLL, PC
论文数: 0引用数: 0
h-index: 0
机构:Laboratory of Chemical Physics, Building 2 National Institute of Diabetes, Digestive and Kidney Diseases National Institutes of Health, Maryland, 20892, Bethesda
DRISCOLL, PC
GRONENBORN, AM
论文数: 0引用数: 0
h-index: 0
机构:Laboratory of Chemical Physics, Building 2 National Institute of Diabetes, Digestive and Kidney Diseases National Institutes of Health, Maryland, 20892, Bethesda
机构:
Ecole Super Biotechnol Strasbourg, CNRS, UMR 7104, F-67412 Illkirch Graffenstaden, FranceEcole Super Biotechnol Strasbourg, CNRS, UMR 7104, F-67412 Illkirch Graffenstaden, France
Atkinson, RA
Kieffer, B
论文数: 0引用数: 0
h-index: 0
机构:
Ecole Super Biotechnol Strasbourg, CNRS, UMR 7104, F-67412 Illkirch Graffenstaden, FranceEcole Super Biotechnol Strasbourg, CNRS, UMR 7104, F-67412 Illkirch Graffenstaden, France
机构:Laboratory of Chemical Physics, Building 2 National Institute of Diabetes, Digestive and Kidney Diseases National Institutes of Health, Maryland, 20892, Bethesda
CLORE, GM
SZABO, A
论文数: 0引用数: 0
h-index: 0
机构:Laboratory of Chemical Physics, Building 2 National Institute of Diabetes, Digestive and Kidney Diseases National Institutes of Health, Maryland, 20892, Bethesda
SZABO, A
BAX, A
论文数: 0引用数: 0
h-index: 0
机构:Laboratory of Chemical Physics, Building 2 National Institute of Diabetes, Digestive and Kidney Diseases National Institutes of Health, Maryland, 20892, Bethesda
BAX, A
KAY, LE
论文数: 0引用数: 0
h-index: 0
机构:Laboratory of Chemical Physics, Building 2 National Institute of Diabetes, Digestive and Kidney Diseases National Institutes of Health, Maryland, 20892, Bethesda
KAY, LE
DRISCOLL, PC
论文数: 0引用数: 0
h-index: 0
机构:Laboratory of Chemical Physics, Building 2 National Institute of Diabetes, Digestive and Kidney Diseases National Institutes of Health, Maryland, 20892, Bethesda
DRISCOLL, PC
GRONENBORN, AM
论文数: 0引用数: 0
h-index: 0
机构:Laboratory of Chemical Physics, Building 2 National Institute of Diabetes, Digestive and Kidney Diseases National Institutes of Health, Maryland, 20892, Bethesda