New guidelines on dyslipidemia management Comparison of French (HAS) and European (ESC/EAS) guidelines

Total cardiovascular risk estimation using a system such as SCORE is recommended for adults > 40 years of age without evidence of cardiovascular disease, diabetes, chronic kidney disease, severe hypertension or familial hypercholesterolemia. Before treatment, a full lipid profile is recommended, fasting in French guidelines, fasting or non-fasting in European guidelines. LDL-C has to be used as the primary target for treatment. For patients with elevated triglycerides, non-HDL-C level is also recommended as the secondary goal for treatment. In patients of very high and high cardiovascular risk, LDL-C goals are respectively below < 0.70 g/L and < 1.0 g/L. For subjects at very high and high cardiovascular risk, French guidelines do not mention that a >= 50% reduction in 1.01-C should be achieved. Statins ore the treatment of choice to reach LDL-C goals. If the goons not reached on maximally tolerated dose of stotin, combination with another LDL lowering drug, mainly ezetimibe, is recommended Fibrates ore mainly proposed for patients with severe hypertriglyceridemio (TG > 5 g/L after lifestyle changes).