The effect of BK polyomavirus large T antigen on CD4 and CD8 T cells in kidney transplant recipients

被引：6
|
作者：
Foroudi, Maryam Rahimi [2 ]
Yaghobi, Ramin [1 ]
Afshari, Afsoon [3 ]
Roozbeh, Jamshid [3 ]
Miresmaeili, Seyed Mohsen [2 ]
Javid, Amaneh [4 ]
机构：
[1] Shiraz Univ Med Sci, Shiraz Transplant Res Ctr, Shiraz, Iran
[2] Sci & Arts Univ, Biol Dept, Yazd, Iran
[3] Shiraz Univ Med Sci, Shiraz Nephro Urol Res Ctr, Shiraz, Iran
[4] Sci & Arts Univ, Fac Engn & Sci, Dept Biol Sci, Yazd, Iran
来源：
TRANSPLANT IMMUNOLOGY | 2022年 / 74卷
关键词：
BK polyomavirus; Large T antigen; CD4 T cells; CD8 T cells; Kidney transplantation; NUCLEAR-LOCALIZATION SIGNAL; MINOR CAPSID PROTEINS; CLINICAL-COURSE; VIRAL ORIGIN; VIRUS; NEPHROPATHY; ACTIVATION; INFECTION; VIREMIA; RISK;
D O I：
10.1016/j.trim.2022.101655
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Human BK polyomavirus (BKPyV) can affect the machinery of the host cell to induce optimal viral replication or transform them into tumor cells. Reactivation of BKPyV happens due to immunosuppression therapies following renal transplantation which might result in BK polyomavirus nephropathy (BKPyVAN) and allograft loss. The first protein that expresses after entering into host cells and has an important role in pathogenicity is the Large T antigen (LT-Ag). In this review tries to study the molecular and cellular inter-regulatory counteractions especially between CD4 and CD8 T cells, and BKPyV LT-Ag may have role in nephropathy after renal transplantation.
引用
收藏
页数：8
相关论文
共 50 条
  • [21] Effect of storage period of erythrocyte suspensions on the CD4 & CD8 T cells
    Bal, Salih Haldun
    Kumas, Levent Tufan
    Cevhertas, Lacin
    Yilmaz, Izel
    Ellergezen, Pinar Hiz
    Budak, Ferah
    Heper, Yasemin
    Goral, Guher
    Oral, Haluk Barbaros
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2021, 51 : 140 - 140
  • [22] Quantitative analysis of EBV-specific CD4/CD8 T cell numbers, absolute CD4/CD8 T cell numbers and EBV load in solid organ transplant recipients with PLTD
    Sebelin-Wulf, Kathrin
    Nguyen, Tuan D.
    Oertel, Stephan
    Papp-Vary, Matthias
    Trappe, Ralf Ulrich
    Schulzki, Antje
    Pezzutto, Antonio
    Riess, Hanno
    Subklewe, Marion
    TRANSPLANT IMMUNOLOGY, 2007, 17 (03) : 203 - 210
  • [23] Polyomavirus BK-Specific CD4+T Cells Response to VP1 Stimulation in Kidney Transplant Recipients
    Noshadi, Nasrin
    Yaghobi, Ramin
    Afshari, Afsoon
    Forouzanfar, Mohsen
    Soleimanian, Saeede
    IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY, 2024, 23 (03) : 272 - 287
  • [24] CD4 and CD8 T Cells: Respectively Reprogrammed and Recapitulated in the Neonate to Induce Transplant Tolerance
    Bascom, R.
    Tao, K.
    West, L.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2017, 17 : 708 - 708
  • [25] Activated CD8 T cells can stimulate CD4 T cells by direct interaction
    Romagnoli, Pablo Alberto
    Altman, John D.
    JOURNAL OF IMMUNOLOGY, 2007, 178
  • [26] ROLE OF CD4 AND CD8 IN ENHANCING T-CELL RESPONSES TO ANTIGEN
    PARNES, JR
    VONHOEGEN, P
    MICELI, MC
    ZAMOYSKA, R
    IMMUNOLOGICAL RECOGNITION, PTS 1 AND 2, 1989, 54 : 649 - 655
  • [27] CD4 T cells guarantee optimal competitive fitness of CD8 memory T cells
    Johansen, P
    Stamou, P
    Tascon, RE
    Lowrie, DB
    Stockinger, B
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2004, 34 (01) : 91 - 97
  • [28] Role of CD4 T cell help in the differentiation of memory CD8 T cells
    Choo, Daniel
    FASEB JOURNAL, 2008, 22
  • [29] ROLE OF CD4 AND CD8 IN ENHANCING T-CELL RESPONSES TO ANTIGEN
    PARNES, JR
    VONHOEGEN, P
    MICELI, MC
    ZAMOYSKA, R
    COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1989, 54 : 649 - 655
  • [30] Genomic difference of CD4 CD8 double-positive T cells versus conventional CD4 T cells and CD8 T cells in responders undergoing immunotherapy in advanced HCC.
    Ting, Vox
    Wong, Carmen Chak-Lui
    Kwong, Yok Lam
    Yau, Thomas Chung Cheung
    CANCER RESEARCH, 2021, 81 (13)
12345