The effect of BK polyomavirus large T antigen on CD4 and CD8 T cells in kidney transplant recipients

被引：7
作者：
Foroudi, Maryam Rahimi [2 ]
Yaghobi, Ramin [1 ]
Afshari, Afsoon [3 ]
Roozbeh, Jamshid [3 ]
Miresmaeili, Seyed Mohsen [2 ]
Javid, Amaneh [4 ]
机构：
[1] Shiraz Univ Med Sci, Shiraz Transplant Res Ctr, Shiraz, Iran
[2] Sci & Arts Univ, Biol Dept, Yazd, Iran
[3] Shiraz Univ Med Sci, Shiraz Nephro Urol Res Ctr, Shiraz, Iran
[4] Sci & Arts Univ, Fac Engn & Sci, Dept Biol Sci, Yazd, Iran
来源：
TRANSPLANT IMMUNOLOGY | 2022年 / 74卷
关键词：
BK polyomavirus; Large T antigen; CD4 T cells; CD8 T cells; Kidney transplantation; NUCLEAR-LOCALIZATION SIGNAL; MINOR CAPSID PROTEINS; CLINICAL-COURSE; VIRAL ORIGIN; VIRUS; NEPHROPATHY; ACTIVATION; INFECTION; VIREMIA; RISK;
D O I：
10.1016/j.trim.2022.101655
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Human BK polyomavirus (BKPyV) can affect the machinery of the host cell to induce optimal viral replication or transform them into tumor cells. Reactivation of BKPyV happens due to immunosuppression therapies following renal transplantation which might result in BK polyomavirus nephropathy (BKPyVAN) and allograft loss. The first protein that expresses after entering into host cells and has an important role in pathogenicity is the Large T antigen (LT-Ag). In this review tries to study the molecular and cellular inter-regulatory counteractions especially between CD4 and CD8 T cells, and BKPyV LT-Ag may have role in nephropathy after renal transplantation.
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页数：8
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