Phosphatases and solid tumors: focus on glioblastoma initiation, progression and recurrences

被引：16

作者：

Dedobbeleer, Matthias ^{[1
]}

Willems, Estelle ^{[1
]}

Freeman, Stephen ^{[2
]}

Lombard, Arnaud ^{[1
,3
,4
]}

Goffart, Nicolas ^{[4
,5
,6
,7
]}

Rogister, Bernard ^{[1
,4
,8
]}

机构：

[1] Univ Liege, GIGA Neurosci Res Ctr, Lab Nervous Syst Disorders & Therapy, Liege, Belgium

[2] Univ Liege, GIGA Neurosci Res Ctr, Lab Dev Neurobiol, Liege, Belgium

[3] CHU, Dept Neurosurg, Liege, Belgium

[4] Univ Liege, Liege, Belgium

[5] CHU, Human Genet, Liege, Belgium

[6] Brain Ctr Rudolf Magnus Inst Neurosci, Dept Neurosurg, Utrecht, Netherlands

[7] Univ Med Ctr, T&P Bohnenn Lab Neurooncol, Utrecht, Netherlands

[8] CHU, Dept Neurol, Liege, Belgium

来源：

BIOCHEMICAL JOURNAL | 2017年 / 474卷

关键词：

DUAL-SPECIFICITY PHOSPHATASE; PROTEIN-KINASE PHOSPHATASE-1; HUMAN OVARIAN-CANCER; CELL LUNG-CANCER; INTEGRATED GENOMIC ANALYSIS; SIGNAL-REGULATED KINASE; NEGATIVE BREAST-CANCER; HIGH-GRADE GLIOMA; STEM-LIKE CELLS; PROSTATE-CANCER;

D O I：

10.1042/BCJ20170112

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphatases and cancer have been related for many years now, as these enzymes regulate key cellular functions, including cell survival, migration, differentiation and proliferation. Dysfunctions or mutations affecting these enzymes have been demonstrated to be key factors for oncogenesis. The aim of this review is to shed light on the role of four different phosphatases (PTEN, PP2A, CDC25 and DUSP1) in five different solid tumors (breast cancer, lung cancer, pancreatic cancer, prostate cancer and ovarian cancer), in order to better understand the most frequent and aggressive primary cancer of the central nervous system, glioblastoma.

引用

页码：2903 / 2924

页数：22

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