Green Synthesis of Gold Nanoparticles Using Carrageenan Oligosaccharide and Their In Vitro Antitumor Activity

被引：70

作者：

Chen, Xiangyan ^{[1
,2
,3
]}

Zhao, Xia ^{[1
,2
,3
]}

Gao, Yanyun ^{[1
,2
,3
]}

Yin, Jiaqi ^{[1
,2
,3
]}

Bai, Mingyue ^{[1
,2
,3
]}

Wang, Fahe ^{[4
]}

机构：

[1] Ocean Univ China, Shandong Prov Key Lab Glycosci & Glycoengn, Qingdao 266003, Peoples R China

[2] Ocean Univ China, Sch Med & Pharm, Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Peoples R China

[3] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266237, Peoples R China

[4] Qingdao Brightmoon Seaweed Grp Co Ltd, State Key Lab Bioact Seaweed Subst, Qingdao 266400, Peoples R China

来源：

MARINE DRUGS | 2018年 / 16卷 / 08期

关键词：

carrageenan oligosaccharide; gold nanoparticles; response surface methodology; green synthesis; anti-tumor activity; SILVER; IMMUNOMODULATION; POLYSACCHARIDES; BIOSYNTHESIS; BIOPOLYMER; CHITOSAN; SULFATE; DRUG;

D O I：

10.3390/md16080277

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Gold nanoparticles (AuNPs) have been widely used in catalysis, photothermal therapy, and targeted drug delivery. Carrageenan oligosaccharide (CAO) derived from marine red algae was used as a reducing and capping agent to obtain AuNPs by an eco-friendly, efficient, and simple synthetic route for the first time. The synthetic conditions of AuNPs were optimized by response surface methodology (RSM), and the CAO-AuNPs obtained were demonstrated to be ellipsoidal, stable and crystalline by means of transmission electron microscopy (TEM), scanning electron microscopy (SEM) and X-ray diffraction (XRD). The CAO-AuNPs showed localized surface plasmon resonance (LSPR) oscillation at about 530 nm with a mean diameter of 35 +/- 8 nm. The zeta potential of CAO-AuNPs was around -20 mV, which was related to the negatively charged CAO around AuNPs. The CAO-AuNPs exhibited significant cytotoxic activities to HCT-116 and MDA-MB-231 cells, which could be a promising nanomaterial for drug delivery.

引用

页数：13

共 44 条

[1] Green synthesis of silver and gold nanoparticles employing levan, a biopolymer from Acetobacter xylinum NCIM 2526, as a reducing agent and capping agent
Ahmed, Khan Behlol Ayaz
Kalla, Divya
Uppuluri, Kiran Babu
Anbazhagan, Veerappan
[J]. CARBOHYDRATE POLYMERS, 2014, 112 : 539 - 545
[2] Biosynthesis of gold nanoparticles: A green approach
Ahmed, Shakeel
Annu
Ikram, Saiqa
Yudha, Salprima S.
[J]. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2016, 161 : 141 - 153
[3] Dual photoacoustic/ultrasound multi-parametric imaging from passion fruit-like nano-architectures
Armanetti, Paolo
Pocovi-Martinez, Salvador
Flori, Alessandra
Avigo, Cinzia
Cassano, Domenico
Menichetti, Luca
Voliani, Valerio
[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2018, 14 (06) : 1787 - 1795
[4] Synthesis and Radical Polymerization of Adamantyl Methacrylate Monomers Having Hemiacetal Moieties
Barkakaty, Balaka
Matsumoto, Kozo
Endo, Takeshi
[J]. MACROMOLECULES, 2009, 42 (24) : 9481 - 9485
[5] Biological properties of "naked" metal nanoparticles
Bhattacharya, Resham
Mukherjee, Priyabrata
[J]. ADVANCED DRUG DELIVERY REVIEWS, 2008, 60 (11) : 1289 - 1306
[6] Carrageenans: Biological properties, chemical modifications and structural analysis - A review
Campo, Vanessa Leiria
Kawano, Daniel Fabio
da Silva, Dilson Braz, Jr.
Carvalho, Ivone
[J]. CARBOHYDRATE POLYMERS, 2009, 77 (02) : 167 - 180
[7] Passion fruit-like nano-architectures: a general synthesis route
Cassano, D.
David, J.
Luin, S.
Voliani, V.
[J]. SCIENTIFIC REPORTS, 2017, 7
[8] Extracellular biosynthesis of gold nanoparticles using sugar beet pulp
Castro, Laura
Luisa Blazquez, M.
Gonzalez, Felisa
Munoz, Jesus A.
Ballester, Antonio
[J]. CHEMICAL ENGINEERING JOURNAL, 2010, 164 (01) : 92 - 97
[9] Controlled synthesis and biomolecular probe application of gold nanoparticles
Dung The Nguyen
Kim, Dong-Joo
Kim, Kyo-Seon
[J]. MICRON, 2011, 42 (03) : 207 - 227
[10] Estela C. B, 2016, J NANOMATER MOL NANO, V5, P4

← 1 2 3 4 5 →