Immunological options for the treatment of tuberculosis: evaluation of novel therapeutic approaches

被引：9

作者：

Achkar, Jacqueline M.

Casadevall, Arturo

Glatman-Freedman, Aharona

机构：

[1] Albert Einstein Coll Med, Div Infect Dis, Dept Pediat, Bronx, NY 10461 USA

[2] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA

[3] Albert Einstein Coll Med, Dept Med, Bronx, NY 10461 USA

[4] Albert Einstein Coll Med, Div Infect Dis, Dept Med, Bronx, NY 10461 USA

来源：

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY | 2007年 / 5卷 / 03期

关键词：

antibodies; cytokines; immunotherapy; tuberculosis;

D O I：

10.1586/14787210.5.3.461

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The emergence of multidrug-resistant tuberculosis strains and the coinfection with HIV, together with advances in immunology, have led to renewed interest regarding ways to exploit the immune responses against Mycobacterium tuberculosis therapeutically. Here we review the fundamentals of tuberculosis therapy in view of the epidemiological and clinical challenges, and explore the experience with immune-based therapies for the treatment of active tuberculosis. These immune-based therapies are discussed here with the aim of assessing their potential use as adjuncts to chemotherapy.

引用

页码：461 / 474

页数：14

共 122 条

[1] ADMINISTRATION OF RECOMBINANT INTERLEUKIN-2 REDUCES THE LOCAL PARASITE LOAD OF PATIENTS WITH DISSEMINATED CUTANEOUS LEISHMANIASIS [J].