Will seizure control improve by switching from the modified Atkins diet to the traditional ketogenic diet?

被引：40

作者：

Kossoff, Eric H. ^{[1
]}

Bosarge, Jennifer L. ^{[1
]}

Miranda, Maria J. ^{[2
]}

Wiemer-Kruel, Adelheid ^{[3
]}

Kang, Hoon Chul ^{[4
]}

Kim, Heung Dong ^{[5
]}

机构：

[1] Johns Hopkins Univ, Baltimore, MD USA

[2] Danish Epilepsy Ctr, Dianalund, Denmark

[3] Epilepsiezentruk Kork, Epilepsy, Kork, Germany

[4] Severance Childrens Hosp, Pediat Epilepsy Clin, Seoul, South Korea

[5] Yonsei Univ, Coll Med, Dept Pediat, Seoul, South Korea

来源：

EPILEPSIA | 2010年 / 51卷 / 12期

关键词：

Modified Atkins; Myoclonic astatic; Doose; Ketogenic; Epilepsy; Intractable; MYOCLONIC-ASTATIC EPILEPSY; CHILDHOOD; EFFICACY;

D O I：

10.1111/j.1528-1167.2010.02774.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

P>It has been reported that children can maintain seizure control when the ketogenic diet (KD) is transitioned to the less-restrictive modified Atkins diet (MAD). What is unknown, however, is the likelihood of additional seizure control from a switch from the MAD to the KD. Retrospective information was obtained from 27 patients who made this dietary change from four different institutions. Ten (37%) patients had >= 10% additional seizure reduction with the KD over the MAD, of which five became seizure-free. The five children who did not improve on the MAD failed to improve when transitioned to the KD. A higher incidence of improvement with the KD occurred for those with myoclonic-astatic epilepsy (70% vs. 12% for all other etiologies, p = 0.004), including all who became seizure-free. These results suggest that the KD probably represents a "higher dose" of dietary therapy than the MAD, which may particularly benefit those with myoclonic-astatic epilepsy.

引用

页码：2496 / 2499

页数：4

共 13 条

[1] Efficacy of the ketogenic diet as a treatment option for epilepsy: Meta-analysis [J].