Effect of Statins on Recurrent Venous Thromboembolism (from the COMMAND VTE Registry)

被引：5

作者：

Yoshikawa, Yusuke ^{[1
]}

Yamashita, Yugo ^{[1
]}

Morimoto, Takeshi ^{[2
]}

Mabuchi, Hiroshi ^{[3
]}

Amano, Hidewo ^{[4
]}

Takase, Toru ^{[5
]}

Hiramori, Seiichi ^{[6
]}

Kim, Kitae ^{[7
]}

Oi, Maki ^{[8
]}

Akao, Masaharu ^{[9
]}

Kobayashi, Yohei ^{[10
]}

Toyofuku, Mamoru ^{[11
]}

Izumi, Toshiaki ^{[12
]}

Tada, Tomohisa ^{[13
]}

Chen, Po-Min ^{[14
]}

Murata, Koichiro ^{[15
]}

Tsuyuki, Yoshiaki ^{[16
]}

Saga, Syunsuke ^{[17
]}

Nishimoto, Yuji ^{[17
]}

Sasa, Tomoki ^{[18
]}

Sakamoto, Jiro ^{[19
]}

Kinoshita, Minako ^{[20
]}

Togi, Kiyonori ^{[21
]}

Takabayashi, Kensuke ^{[22
]}

Shiomi, Hiroki ^{[1
]}

Kato, Takao ^{[1
]}

Makiyama, Takeru ^{[1
]}

Ono, Koh ^{[1
]}

Murakami, Tomoyuki ^{[3
]}

Kimura, Takeshi ^{[1
]}

机构：

[1] Kyoto Univ, Dept Cardiovasc Med, Grad Sch Med, Kyoto, Japan

[2] Hyogo Coll Med, Dept Clin Epidemiol, Nishinomiya, Hyogo, Japan

[3] Koto Mem Hosp, Dept Cardiol, Higashiomi, Japan

[4] Kurashiki Cent Hosp, Dept Cardiovasc Med, Kurashiki, Okayama, Japan

[5] Kinki Univ Hosp, Dept Cardiol, Osaka, Japan

[6] Kokura Mem Hosp, Dept Cardiol, Kokura, Japan

[7] Kobe City Med Ctr Gen Hosp, Dept Cardiovasc Med, Kobe, Hyogo, Japan

[8] Japanese Red Cross Otsu Hosp, Dept Cardiol, Otsu, Shiga, Japan

[9] Natl Hosp Org Kyoto Med Ctr, Dept Cardiol, Kyoto, Japan

[10] Osaka Red Cross Hosp, Dept Cardiovasc Ctr, Osaka, Japan

[11] Japanese Red Cross Wakayama Med Ctr, Dept Cardiol, Wakayama, Japan

[12] Kitano Hosp, Cardiovasc Ctr, Tazuke Kofukai Med Res Inst, Osaka, Japan

[13] Shizuoka Prefectural Gen Hosp, Dept Cardiol, Shizuoka, Japan

[14] Osaka Saiseikai Noe Hosp, Dept Cardiol, Osaka, Japan

[15] Shizuoka City Shizuoka Hosp, Dept Cardiol, Shizuoka, Japan

[16] Shimada Municipal Hosp, Div Cardiol, Shimada, Japan

[17] Hyogo Prefectural Amagasaki Gen Med Ctr, Dept Cardiol, Amagasaki, Hyogo, Japan

[18] Kishiwada City Hosp, Dept Cardiol, Kishiwada, Japan

[19] Tenri Hosp, Dept Cardiol, Tenri, Nara, Japan

[20] Nishikobe Med Ctr, Dept Cardiol, Kobe, Hyogo, Japan

[21] Kinki Univ, Nara Hosp, Div Cardiol, Fac Med, Ikoma, Japan

[22] Hirakata Kohsai Hosp, Dept Cardiol, Hirakata, Osaka, Japan

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2020年 / 125卷 / 02期

关键词：

ACUTE PULMONARY-EMBOLISM; DEEP-VEIN THROMBOSIS; REAL-WORLD; RISK; PREVENTION; MANAGEMENT; DIAGNOSIS; POPULATION; GUIDELINES; OUTCOMES;

D O I：

10.1016/j.amjcard.2019.10.011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Statins, which are considered as essential for primary and secondary prevention of atherosclerotic diseases, were also reported to reduce first venous thromboembolism (VTE). However, the effect of statins on VTE recurrence remains conflicting. We aimed to examine the association between statin use and VTE recurrence in a large observational study in Japan. The COMMAND VTE Registry is a multicenter registry enrolling consecutive 3027 patients with acute symptomatic VTE in 29 centers in Japan between January 2010 and August 2014. In the current study, the entire cohort was divided into statin group (N = 437) and no-statin group (N = 2590) according to the status of statin use at baseline. The statin group as compared with the no-statin group was older (statin group 71.2 vs no-statin group 66.5 years, p<0.001), included more women (67% vs 60%, p = 0.008), and less frequently had active cancer (12% vs 25%, p<0.001). There was no significant difference in the clinical presentation of VTE (pulmonary embolism, 58% vs 56%, p = 0.44). The cumulative 3-year incidence of recurrent VTE was significantly lower in the statin group than the no-statin group (3.8% vs 8.8%, p<0.001). After adjusting for confounders including active cancer, statin use was associated with significantly lower risk for recurrent VTE (Hazard ratio 0.49, 95% confidence interval 0.29 to 0.78, p = 0.002). The results were consistent in a sensitivity sub-group analysis with and without active cancer. In conclusion, statin use was associated with significantly lower risk for the recurrent VTE in patients with VTE. (C) 2019 Elsevier Inc. All rights reserved.

引用

页码：189 / 197

页数：9

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