Management of Acute Myeloid Leukemia: A Review for General Practitioners in Oncology

被引：56
作者：
Stubbins, Ryan J. [1 ,2 ]
Francis, Annabel [3 ]
Kuchenbauer, Florian [1 ,2 ,4 ]
Sanford, David [1 ,2 ]
机构：
[1] BC Canc, Vancouver Coastal Hlth, Leukemia BMT Program British Columbia, Vancouver, BC V5Z 1M9, Canada
[2] Univ British Columbia, Dept Med, Div Hematol, Vancouver, BC V5Z 1M9, Canada
[3] Fraser Hlth, Vancouver Coastal Hlth, Leukemia BMT Program British Columbia, Vancouver, BC V5Z 1M9, Canada
[4] British Columbia Canc Res Ctr, Terry Fox Lab, Vancouver, BC V5Z 1L3, Canada
来源：
CURRENT ONCOLOGY | 2022年 / 29卷 / 09期
关键词：
acute myeloid leukemia; targeted therapy; chemotherapy; stem cell transplant; palliative care; OF-LIFE CARE; PALLIATIVE CARE; GEMTUZUMAB OZOGAMICIN; ADULT PATIENTS; ALLOGENEIC TRANSPLANTATION; MARROW-TRANSPLANTATION; CELL TRANSPLANTATION; OPEN-LABEL; CHEMOTHERAPY; INDUCTION;
D O I：
10.3390/curroncol29090491
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Acute myeloid leukemia (AML) is a hematologic malignancy that most frequently develops in older adults. Overall, AML is associated with a high mortality although advancements in genetic risk stratification and new treatments are leading to improvements in outcomes for some subgroups. In this review, we discuss an individualized approach to intensive therapy with a focus on the role of recently approved novel therapies as well as the selection of post-remission therapies for patients in first remission. We discuss the management of patients with relapsed and refractory AML, including the role of targeted treatment and allogeneic stem cell transplant. Next, we review non-intensive treatment for older and unfit AML patients including the use of azacitidine and venetoclax. Finally, we discuss the integration of palliative care in the management of patients with AML.
引用
收藏
页码：6245 / 6259
页数：15
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