Apolipoprotein E genotype in patients with Alzheimer's disease

被引：0

作者：

Luo, BY ^{[1
]}

Chen, Z

Zhang, YY

Pan, XP

Li, X

Chen, F

机构：

[1] Zhejiang Univ, Affiliated Hosp 1, Coll Med, Dept Neurol, Hangzhou 310003, Peoples R China

[2] Zhejiang Univ, Affiliated Hosp 1, Coll Med, Inst Infect Dis, Hangzhou 310003, Peoples R China

来源：

CHINESE MEDICAL JOURNAL | 2003年 / 116卷 / 08期

关键词：

Alzheimer disease; genetics; apolipoprotein E; single nucleotide polymorphism;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective To explore the frequency and significance of ApoE gene polymorphisms in patients with sporadic Alzheimer's disease (AD). Methods Single nucleotide polymorphisms of the ApoE gene were analyzed in 32 cases of AD and 26 controls, using PCR and gene sequencing. Results The single nucleotide polymorphism of ApoE gene 462C/G was significantly associated with AD (P<0.05). Conclusions The 462C/G polymorphism might be a specific genotype in Chinese patients with sporadic AD.

引用

页码：1220 / 1222

页数：3

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