Role of the M2 haplotype within the annexin A5 gene in the occurrence of pregnancy-related venous thromboembolism

被引：25

作者：

Grandone, Elvira ^{[1
]}

Tiscia, Giovanni ^{[1
]}

Colaizzo, Donatella ^{[1
]}

Chinni, Elena ^{[1
]}

Pisanelli, Daniela ^{[1
]}

Bafunno, Valeria ^{[2
]}

Margaglione, Maurizio ^{[1
,2
]}

机构：

[1] Ist Ricovero & Cura Carattere Sci, Unita Aterosclerosi & Trombosi, Res Dept, I-71013 S Giovanni Rotondo Foggi, Italy

[2] Univ Foggia, Div Med Genet, Dept Biomed Sci, Foggia, Italy

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2010年 / 203卷 / 05期

关键词：

annexin A5; deep venous thrombosis; haplotypes; pregnancy-related deep venous thrombosis; COMMON HAPLOTYPE; RISK-FACTORS; ANXA5; GENE; V BINDING; THROMBOSIS; THROMBOPHILIA; POPULATION; EXPRESSION;

D O I：

10.1016/j.ajog.2010.06.007

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

OBJECTIVE: Knowledge about risk factors for venous thromboembolism (VTE) is still limited. A recently found haplotype within the natural anticoagulant protein annexin A5 (ANXA5) exerts an important modulating effect on gene expression. STUDY DESIGN: Eighty-three nonanticoagulated patients with a documented pregnancy-related VTE and 195 controls were investigated. The presence of the ANXA5 haplotypes was determined. RESULTS: Twenty-seven patients (32.5%) carried the M2 haplotype. Among them, 17 (63.0%) had a history of VTE in puerperium and 10 (37.0%) during pregnancy. The prevalence of the M2 haplotype was different as compared with that recorded among controls (odds ratio, 2.7; 95% confidence interval, 1.5-4.9, P < .001). A logistic regression analysis, correcting for potential confounders (age at which the thrombotic event occurred, factor V Leiden, and factor IIA20210 variants) showed a significant increase (odds ratio, 3.4; 95% confidence interval, 1.7-6.7) of the occurrence of VTE in carriers of the M2 haplotype as compared with noncarriers. CONCLUSION: The M2 haplotype within the ANXA5 gene may represent a new thrombophilic risk factor for pregnancy-related VTE.

引用

页码：461.e1 / 461.e5

页数：5

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