Vancomycin-loaded chitosan aerogel particles for chronic wound applications

被引：149

作者：

Lopez-Iglesias, Clara ^{[1
,2
]}

Barros, Joana ^{[3
,4
]}

Ardao, Ines ^{[5
]}

Monteiro, Fernando J. ^{[3
,4
]}

Alvarez-Lorenzo, Carmen ^{[1
,2
]}

Gomez-Amoza, Jose L. ^{[1
,2
]}

Garcia-Gonzalez, Carlos A. ^{[1
,2
]}

机构：

[1] Univ Santiago de Compostela, Fac Farm, R D Pharma Grp GI 1645, Dept Farmacol Farm & Tecnol Farmaceut, E-15782 Santiago De Compostela, Spain

[2] Univ Santiago de Compostela, Hlth Res Inst Santiago de Compostela IDIS, E-15782 Santiago De Compostela, Spain

[3] Univ Porto, I3S, FEUP Fac Engn, P-4200135 Porto, Portugal

[4] INEB Inst Engn Biomed, P-4200135 Porto, Portugal

[5] Univ Santiago de Compostela, Ctr Singular Invest Med Mol & Enfermedades Cron C, BioFanna Res Grp, E-15782 Santiago De Compostela, Spain

来源：

CARBOHYDRATE POLYMERS | 2019年 / 204卷

关键词：

Chitosan; Aerogel; Chronic wounds; Antimicrobial; ANTIBACTERIAL ACTIVITY; DRESSING APPLICATIONS; TOPICAL VANCOMYCIN; MOLECULAR-WEIGHT; DELIVERY-SYSTEMS; DRUG-DELIVERY; COTTON GAUZES; SURFACE-AREA; ANTIBIOTICS; INFECTION;

D O I：

10.1016/j.carbpol.2018.10.012

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Chronic wounds are a prevailing cause of decreased quality of life, being microbial burden a factor hindering the normal wound healing process. Aerogels are nanostructured materials with large surface area (> 250m(2)/g) and high porosity (> 96%). In this work, vancomycin-loaded chitosan aerogel beads were tested as a potential formulation to treat and prevent infections at the wound site. Processing of chitosan in the form of aerogels endowed this polysaccharide with enhanced water sorption capacity and air permeability. The morphological and textural properties of the particles were studied by image and N-2 adsorption-desorption analysis and scanning electron microscopy. Vancomycin content and release profiles from aerogel carriers showed a fast drug release that permitted to efficiently achieve local therapeutic levels. Cell studies with fibroblasts and antimicrobial tests against S. aureus showed that the vancomycin-loaded aerogel particles were cytocompatible and effective in preventing high bacterial loads at the wound site.

引用

页码：223 / 231

页数：9

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