An efficient method for 4 beta-anilino-4'-demethylepipodophyllotoxins: Synthesis of NPF and W-68

被引：79

作者：

Kamal, A

Gayatri, NL

机构：

[1] Division of Organic Chemistry, Indian Inst. of Chemical Technology

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 19期

关键词：

D O I：

10.1016/0040-4039(96)00546-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

4 beta-Substituted podophyllotoxin congeners have been obtained with significant stereoselectivity and improved yields by employing Bu(4)N(+)I(-) in the displacement reaction of the 4-bromoepipodophyllotoxin. The DNA topoisomerase II inhibitors, NPF and W-68 have been prepared in good yields by this method. (C) 1996 Published by Elsevier Science Ltd

引用

页码：3359 / 3362

页数：4

共 18 条

[1]

[Anonymous], 1980, ANTICANCER AGENTS BA

[2] ASYMMETRIC TOTAL SYNTHESIS OF (-)-PODOPHYLLOTOXIN [J].