Emerging concepts and latest advances regarding the etiopathogenesis, morphology and immunophenotype of basal cell carcinoma

被引:0
作者
Costache, Mariana [1 ,2 ]
Georgescu, Tiberiu Augustin [1 ,2 ]
Oproiu, Ana Maria [2 ,3 ]
Costache, Diana [2 ]
Naie, Alexandru [2 ]
Sajin, Maria [1 ,2 ]
Nica, Adriana Elena [2 ,4 ]
机构
[1] Univ Emergency Hosp, Dept Pathol, 169 Independentei Ave, Bucharest 050098, Romania
[2] Carol Davila Univ Med & Pharm, Bucharest, Romania
[3] Univ Emergency Hosp, Dept Plast Surg, 169 Independentei Ave, Bucharest 050098, Romania
[4] Univ Emergency Hosp, Dept Anesthesiol & Intens Care, Bucharest, Romania
关键词
basal cell carcinoma; Rombo syndrome; Bazex syndrome; nevoid basal cell syndrome; NONMELANOMA SKIN-CANCER; OF-THE-LITERATURE; CLEAR-CELL; ROMBO-SYNDROME; PINKUS; FIBROEPITHELIOMA; VARIANT; TRICHOEPITHELIOMAS; DIFFERENTIATION; EPIDEMIOLOGY;
D O I
暂无
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Basal cell carcinoma (BCC) represents the most common skin malignancy, which has been linked over time to multifactorial causes. It usually occurs on sun-exposed areas in people with fair skin and with predilection for men. BCC usually affects elderly patients and has an extremely wide range of histological subtypes, which can present clinically under different variants, some with really challenging differentials. Although BCC may occur in familial settings, such as nevoid BCC syndrome, Rombo or Bazex-Dupre-Christol syndromes, nonsyndromic multiple BCCs have also been described in the scientific literature. In this review, we discuss in detail the latest scientific concepts regarding BCC, its etiology, pathogenesis, genetic bases of disease, morphology and immunophenotype, as well as the currently known genetic syndromes, which may lead to development of multiple BCCs, especially in young adults.
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页码:427 / 433
页数:7
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