HSP100/Clp proteins: A common mechanism explains diverse functions

被引：450

作者：

Schirmer, EC ^{[1
]}

Glover, JR ^{[1
]}

Singer, MA ^{[1
]}

Lindquist, S ^{[1
]}

机构：

[1] UNIV CHICAGO, DEPT MOL GENET & CELL BIOL, CHICAGO, IL 60637 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1996年 / 21卷 / 08期

关键词：

D O I：

10.1016/0968-0004(96)10038-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The HSP100/Clp proteins are a newly discovered family with a great diversity of functions, such as increased tolerance to high temperatures, promotion of proteolysis of specific cellular substrates and regulation of transcription. HSP100/Clp proteins are also synthesized in a variety of specific patterns and, in eukaryotes, are localized to different subcellular compartments. Recent data suggest that a common ability to disassemble higher-order protein structures and aggregates unifies the molecular functions of this diverse family.

引用

页码：289 / 296

页数：8

共 50 条

[1]

[Anonymous], 1992, MacClade: Analysis of phylogeny and character evolution

[2] PROTEIN-DNA ASSEMBLIES CONTROLLING LYTIC DEVELOPMENT OF BACTERIOPHAGE-MU [J].

BAKER, TA .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 1993, 3 (05) :708-712

[3] ROLE OF THE CHAPERONE PROTEIN HSP104 IN PROPAGATION OF THE YEAST PRION-LIKE FACTOR [PSI(+)] [J].

CHERNOFF, YO ;

LINDQUIST, SL ;

ONO, B ;

INGEVECHTOMOV, SG ;

LIEBMAN, SW .

SCIENCE, 1995, 268 (5212) :880-884

[4] CYTOPLASMIC INHERITANCE - PRION-LIKE FACTORS IN YEAST [J].

COX, B .

CURRENT BIOLOGY, 1994, 4 (08) :744-748

[5] FUNCTIONAL-SIGNIFICANCE OF SYMMETRICAL VERSUS ASYMMETRICAL GROEL-GROES CHAPERONIN COMPLEXES [J].

ENGEL, A ;

HAYERHARTL, MK ;

GOLDIE, KN ;

PFEIFER, G ;

HEGERL, R ;

MULLER, S ;

DASILVA, ACR ;

BAUMEISTER, W ;

HARTL, FU .

SCIENCE, 1995, 269 (5225) :832-836

[6] PROTEIN FOLDING IN THE CELL [J].

GETHING, MJ ;

SAMBROOK, J .

NATURE, 1992, 355 (6355) :33-45

[7] VIRULENCE IN BACTERIOPHAGE-MU - A CASE OF TRANSDOMINANT PROTEOLYSIS BY THE ESCHERICHIA-COLI CLP-SERINE PROTEASE [J].

GEUSKENS, V ;

MHAMMEDIALAOUI, A ;

DESMET, L ;

TOUSSAINT, A .

EMBO JOURNAL, 1992, 11 (13) :5121-5127

[8] CONSERVATION OF THE REGULATORY SUBUNIT FOR THE CLP ATP-DEPENDENT PROTEASE IN PROKARYOTES AND EUKARYOTES [J].

GOTTESMAN, S ;

SQUIRES, C ;

PICHERSKY, E ;

CARRINGTON, M ;

HOBBS, M ;

MATTICK, JS ;

DALRYMPLE, B ;

KURAMITSU, H ;

SHIROZA, T ;

FOSTER, T ;

CLARK, WP ;

ROSS, B ;

SQUIRES, CL ;

MAURIZI, MR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (09) :3513-3517

[9]

GOTTESMAN S, 1993, J BIOL CHEM, V268, P22618

[10] EXPRESSION OF THE PASTEURELLA-HAEMOLYTICA LEUKOTOXIN IS INHIBITED BY A LOCUS THAT ENCODES AN ATP-BINDING CASSETTE HOMOLOG [J].

HIGHLANDER, SK ;

WICKERSHAM, EA ;

GARZA, O ;

WEINSTOCK, GM .

INFECTION AND IMMUNITY, 1993, 61 (09) :3942-3951

← 1 2 3 4 5 →