First Use of Investigational Antiviral Drug Pocapavir (V-073) for Treating Neonatal Enteroviral Sepsis

被引：33

作者：

Torres-Torres, Sanet ^{[1
]}

Myers, Angela L. ^{[1
]}

Klatte, J. Michael ^{[1
]}

Rhoden, Eric E. ^{[2
]}

Oberste, M. Steven ^{[2
]}

Collett, Marc S. ^{[3
]}

McCulloh, Russell J. ^{[1
]}

机构：

[1] Childrens Mercy, Pediat Infect Dis, Kansas City, MO USA

[2] Ctr Dis Control & Prevent, Atlanta, GA USA

[3] ViroDefense Inc, Rockville, MD USA

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2015年 / 34卷 / 01期

关键词：

neonatal enterovirus infection; pocapavir; coxsackievirus; INFECTION;

D O I：

10.1097/INF.0000000000000497

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neonatal enteroviral sepsis is a potentially fatal condition. Perinatally acquired infection and severe coagulopathy can be associated with a poor clinical outcome, and antiviral therapy is currently unavailable. Pocapavir (V-073) is an investigational drug candidate being developed for poliovirus indications, but also has variable antiviral activity against nonpolio enteroviruses. We describe the first use of pocapavir in treating a case of severe neonatal enteroviral sepsis due to Coxsackievirus B3.

引用

页码：52 / 54

页数：3

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