Wingless signaling: An axin to grind

被引：14
作者：
Jones, WM [1 ]
Bejsovec, A [1 ]
机构：
[1] Duke Univ, Dept Biol, Durham, NC 27708 USA
来源：
CURRENT BIOLOGY | 2003年 / 13卷 / 12期
关键词：
D O I：
10.1016/S0960-9822(03)00407-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Negative regulation of Wingless/Wnt signaling plays an important role in embryonic patterning and is also needed for tumor suppression in adult tissues. New findings in Drosophila reveal a novel mechanism for down-regulating the activity of the Wingless/Wnt pathway.
引用
收藏
页码：R479 / R481
页数：3
相关论文
共 15 条
[1]   Functional interaction of an axin homolog, conductin, with β-catenin, APC, and GSK3β [J].
Behrens, J ;
Jerchow, BA ;
Würtele, M ;
Grimm, J ;
Asbrand, C ;
Wirtz, R ;
Kühl, M ;
Wedlich, D ;
Birchmeier, W .
SCIENCE, 1998, 280 (5363) :596-599
[2]   Armadillo/β-catenin signals in the nucleus -: proof beyond a reasonable doubt? [J].
Bienz, M ;
Clevers, H .
NATURE CELL BIOLOGY, 2003, 5 (03) :179-182
[3]   Drosophila Tcf and Groucho interact to repress Wingless signalling activity [J].
Cavallo, RA ;
Cox, RT ;
Moline, MM ;
Roose, J ;
Polevoy, GA ;
Clevers, H ;
Peifer, M ;
Bejsovec, A .
NATURE, 1998, 395 (6702) :604-608
[4]  
CLIFFE A, 2003, CURR BIOL
[5]   Cellular mechanisms of wingless/Wnt signal transduction [J].
Dierick, H ;
Bejsovec, A .
CURRENT TOPICS IN DEVELOPMENTAL BIOLOGY, VOL 43, 1999, 43 :153-190
[6]   Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and β-catenin [J].
Itoh, K ;
Krupnik, VE ;
Sokol, SY .
CURRENT BIOLOGY, 1998, 8 (10) :591-594
[7]   Axin and Frat1 interact with DvI and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1 [J].
Li, L ;
Yuan, HD ;
Weaver, CD ;
Mao, JH ;
Farr, GH ;
Sussman, DJ ;
Jonkers, J ;
Kimelman, D ;
Wu, DQ .
EMBO JOURNAL, 1999, 18 (15) :4233-4240
[8]   Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway [J].
Mao, JH ;
Wang, JY ;
Liu, B ;
Pan, WJ ;
Farr, GH ;
Flynn, C ;
Yuan, HD ;
Takada, S ;
Kimelman, D ;
Li, L ;
Wu, DQ .
MOLECULAR CELL, 2001, 7 (04) :801-809
[9]  
Pai LM, 1997, DEVELOPMENT, V124, P2255
[10]  
PEIFER M, 1994, DEVELOPMENT, V120, P369
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