Convenient synthesis of the pentasaccharide repeating unit corresponding to the cell wall O-antigen of Escherichia albertii O4

被引：3

作者：

Manna, Tapasi ^{[1
]}

Gucchait, Arin ^{[1
]}

Misra, Anup Kumar ^{[1
]}

机构：

[1] Bose Inst, Div Mol Med, P-1-12,CIT Scheme 7 M, Kolkata 700054, India

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 16卷

关键词：

Escherichia albertii O4; glycosylation; HClO4/SiO2; O-antigen; pentasaccharide; GLYCOSYLATION; OLIGOSACCHARIDES; PATHOGEN; PHASE;

D O I：

10.3762/bjoc.16.12

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A straightforward sequential synthetic strategy has been developed for the synthesis of a pentasaccharide repeating unit corresponding to the cell wall O-antigen of the Escherichia albertii O-4 strain in very good yield with the desired configuration at the glycosidic linkages using thioglycosides and trichloroacetimidate derivatives as glycosyl donors and perchloric acid supported over silica (HClO4/SiO2) as a solid supported protic acid glycosyl activator. The expected configuration at the glycosidic linkages was achieved using a reasonable selection of protecting groups in the manosaccharide intermediates.

引用

页码：106 / 110

页数：5

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