Stimuli responsive polymers for biomedical applications

被引：1452
作者：
Alarcón, CDH [1 ]
Pennadam, S [1 ]
Alexander, C [1 ]
机构：
[1] Univ Portsmouth, Sch Pharm & Biomed Sci, Portsmouth PO1 2DT, Hants, England
来源：
CHEMICAL SOCIETY REVIEWS | 2005年 / 34卷 / 03期
关键词：
D O I：
10.1039/b406727d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Polymers that can respond to external stimuli are of great interest in medicine, especially as controlled drug release vehicles. In this critical review, we consider the types of stimulus response used in therapeutic applications and the main classes of responsive materials developed to date. Particular emphasis is placed on the wide-ranging possibilities for the biomedical use of these polymers, ranging from drug delivery systems and cell adhesion mediators to controllers of enzyme function and gene expression (134 references).
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页码：276 / 285
页数：10
相关论文
共 141 条
[1]   POLY(ETHYLENE OXIDE)-POLY(PROPYLENE OXIDE)-POLY(ETHYLENE OXIDE) BLOCK-COPOLYMER SURFACTANTS IN AQUEOUS-SOLUTIONS AND AT INTERFACES - THERMODYNAMICS, STRUCTURE, DYNAMICS, AND MODELING [J].
ALEXANDRIDIS, P ;
HATTON, TA .
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 1995, 96 (1-2) :1-46
[2]   TEMPERATURE EFFECTS ON STRUCTURAL-PROPERTIES OF PLURONIC P104 AND F108 PEO-PPO-PEO BLOCK-COPOLYMER SOLUTIONS [J].
ALEXANDRIDIS, P ;
NIVAGGIOLI, T ;
HATTON, TA .
LANGMUIR, 1995, 11 (05) :1468-1476
[3]   Switching the inside and the outside of aggregates of water-soluble block copolymers with double thermoresponsivity [J].
Arotçaréna, M ;
Heise, B ;
Ishaya, S ;
Laschewsky, A .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (14) :3787-3793
[4]   Polymer versus monomer as displacer in immobilized metal affinity chromatography [J].
Arvidsson, P ;
Ivanov, AE ;
Galaev, IY ;
Mattiasson, B .
JOURNAL OF CHROMATOGRAPHY B, 2001, 753 (02) :279-285
[5]   ON-OFF THERMOCONTROL OF SOLUTE TRANSPORT .2. SOLUTE RELEASE FROM THERMOSENSITIVE HYDROGELS [J].
BAE, YH ;
OKANO, T ;
KIM, SW .
PHARMACEUTICAL RESEARCH, 1991, 8 (05) :624-628
[6]   INSULIN PERMEATION THROUGH THERMO-SENSITIVE HYDROGELS [J].
BAE, YH ;
OKANO, T ;
KIM, SW .
JOURNAL OF CONTROLLED RELEASE, 1989, 9 (03) :271-279
[7]   Control of flow direction in microfluidic devices with polyelectrolyte multilayers [J].
Barker, SLR ;
Ross, D ;
Tarlov, MJ ;
Gaitan, M ;
Locascio, LE .
ANALYTICAL CHEMISTRY, 2000, 72 (24) :5925-5929
[8]  
BRONDSTED H, 1992, ACS SYM SER, V480, P285
[9]   Release of recombinant human interleukin-2 from dextran-based hydrogels [J].
Cadée, JA ;
de Groot, CJ ;
Jiskoot, W ;
den Otter, W ;
Hennink, WE .
JOURNAL OF CONTROLLED RELEASE, 2002, 78 (1-3) :1-13
[10]   Pharmacokinetic and biodistribution properties of poly(ethylene glycol)-protein conjugates [J].
Caliceti, P ;
Veronese, FM .
ADVANCED DRUG DELIVERY REVIEWS, 2003, 55 (10) :1261-1277
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