Design and validation of fiber optic localized surface plasmon resonance sensor for thyroglobulin immunoassay with high sensitivity and rapid detection

被引：16
作者：
Kim, Hyeong-Min [1 ]
Jeong, Dae Hong [2 ]
Lee, Ho-Young [3 ]
Park, Jae-Hyoung [1 ]
Lee, Seung-Ki [1 ]
机构：
[1] Dankook Univ, Dept Elect & Elect Engn, Yongin 16890, South Korea
[2] Seoul Natl Univ, Dept Chem Educ, Seoul 08826, South Korea
[3] Seoul Natl Univ, Bundang Hosp, Dept Nucl Med, Seongnam 13620, South Korea
来源：
SCIENTIFIC REPORTS | 2021年 / 11卷 / 01期
基金：
新加坡国家研究基金会;
关键词：
GOLD NANOPARTICLES; FOLLOW-UP; LSPR; ENHANCEMENT; BINDING; CANCER;
D O I：
10.1038/s41598-021-95375-y
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A simple optical fiber sensor based on localized surface plasmon resonance was constructed for direct and rapid measurement of thyroglobulin (Tg). Specific tests for Tg in patients that have undergone thyroidectomy are limited because of insufficient sensitivity, complicated procedures, and in some cases, a long time to yield a result. A sensitive, fast, and simple method is necessary to relieve the psychological and physical burden of the patient. Various concentrations of Tg were measured in a microfluidic channel using an optical fiber sensor with gold nanoparticles. The sensor chip has a detection limit of 93.11 fg/mL with no specificity for other antigens. The potential applicability of the Tg sensing system was evaluated using arbitrary samples containing specific concentrations of Tg. Finally, the sensor can be employed to detect Tg in the patient's serum, with a good correlation when compared with the commercial kit.
引用
收藏
页数：9
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