ECR-MAPK Regulation in Liver Early Development

被引：7

作者：

Zhao, Xiu-Ju ^{[1
,2
]}

Zhuo, Hexian ^{[3
]}

机构：

[1] Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Collaborat Innovat Ctr Proc Agr Prod Hubei Prov, Wuhan 430023, Peoples R China

[2] Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China

[3] Xinxiang Inst Drug Control, Xinxiang 453000, Peoples R China

来源：

BIOMED RESEARCH INTERNATIONAL | 2014年 / 2014卷

关键词：

GENE-EXPRESSION; CANCER; ACTIVATION; CXCL13; MODEL;

D O I：

10.1155/2014/850802

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Early growth is connected to a key link between embryonic development and aging. In this paper, liver gene expression profiles were assayed at postnatal day 22 and week 16 of age. Meanwhile another independent animal experiment and cell culture were carried out for validation. Significance analysis of microarrays, qPCR verification, drug induction/inhibition assays, and metabonomics indicated that alpha-2u globulin (extracellular region)-socs2 (-SH2-containing signals/receptor tyrosine kinases)-ppp2r2a/pik3c3 (MAPK signaling)-hsd3b5/cav2 (metabolism/organization) plays a vital role in early development. Taken together, early development of male rats is ECR and MAPK-mediated coordination of cancer-like growth and negative regulations. Our data represent the first comprehensive description of early individual development, which could be a valuable basis for understanding the functioning of the gene interaction network of infant development.

引用

页数：9

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