Cross-reactivity to highly pathogenic avian influenza H5N1 viruses after vaccination with nonadjuvanted and MF59-adjuvanted influenza A/duck/Singapore/97 (H5N3) vaccine: A potential priming strategy

被引：223

作者：

Stephenson, I ^{[1
]}

Bugarini, R

Nicholson, KG

Podda, A

Wood, JM

Zambon, MC

Katz, JM

机构：

[1] Leicester Royal Infirm, Infect Dis Unit, Leicester LE1 SWW, Leics, England

[2] Hlth Protect Agcy, Cent Publ Hlth Lab, Colindale, England

[3] Natl Inst Biol Stand & Controls, Potters Bar EN6 3QG, Herts, England

[4] Chiron Vaccines, Siena, Italy

[5] Ctr Dis Control & Prevent, Influenza Branch, Atlanta, GA USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2005年 / 191卷 / 08期

关键词：

D O I：

10.1086/428948

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antigenically well-matched vaccines against highly pathogenic avian influenza H5N1 viruses are urgently required. Human serum samples after immunization with MF59 or nonadjuvanted A/duck/Singapore/97 (H5N3) vaccine were tested for antibody to 1997-2004 human H5N1 viruses. Antibody responses to 3 doses of nonadjuvanted vaccine were poor and were higher after MF59-adjuvanted vaccine, with seroconversion rates to A/HongKong/156/97, A/HongKong/213/03, A Thailand/16/04, and A/Vietnam/120/04 of 100% (P < .0001), 100% (P < .0001), 71% (P = .0004), and 43% (P = .0128) in 14 subjects, respectively, compared with 27%, 27%, 0% in 11 who received nonadjuvanted vaccine. These findings have implications for the rational design of pandemic vaccines against influenza H5.

引用

页码：1210 / 1215

页数：6

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