COVID-19 Vaccine Effectiveness at a Referral Hospital in Northern Peru: A Retrospective Cohort Study

被引：8

作者：

Valladares-Garrido, Mario J. ^{[1
,2
,3
]}

Zena-Nanez, Sandra ^{[4
]}

Ichiro Peralta, C. ^{[5
]}

Puicon-Suarez, Jacqueline B. ^{[6
]}

Diaz-Velez, Cristian ^{[3
,7
]}

Failoc-Rojas, Virgilio E. ^{[3
,8
]}

机构：

[1] Univ Norbert Wiener, Lima 15046, Peru

[2] Hosp Reg Lambayeque, Chiclayo 14012, Peru

[3] Inst Evaluac Tecnol Salud & Invest IETSI, EsSalud, Lima 15072, Peru

[4] Univ Continental, Sch Med, Huancayo 12001, Peru

[5] Univ Nacl Federico Villarreal, Sch Med, Lima 15088, Peru

[6] Univ Nacl Pedro Ruiz Gallo, Soc Cient Estudiantes Med, Lambayeque 14013, Peru

[7] Univ Privada Antenor Orrego, Sch Med, Trujillo 13008, Peru

[8] Univ San Ignacio Loyola, Lima 15024, Peru

来源：

VACCINES | 2022年 / 10卷 / 05期

基金：

美国国家卫生研究院;

关键词：

vaccination; COVID-19; mortality; vaccine effectiveness; Peru;

D O I：

10.3390/vaccines10050812

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

COVID-19 vaccines have achieved a significant reduction in mortality, yet objective estimates are needed in specific settings. We aimed to determine the effectiveness of COVID-19 vaccination at a referral hospital in Lambayeque, Peru. We conducted a retrospective cohort study from February to September 2021. We included hospitalized patients with COVID-19, whose data were stored in NotiWeb, a patient data system of the Peruvian Ministry of Health. We applied a propensity score-weighting method according to baseline characteristics of patients, and estimated hazard ratios (HR) using Cox regression models. Of 1553 participants, the average age was 55 years (SD: 16.8), 907 (58%) were male, and 592 (38%) deceased at 28-day follow-up. Before hospital admission, 74 (4.8%) had been immunized with at least one vaccine dose. Effectiveness against death in vaccinated patients was 50% at 90-day follow-up (weighted HR 0.50, 95% CI 0.28-0.89). Our results support the effectiveness of COVID-19 vaccination against death and provide information after early immunization in Peru.

引用

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