Simultaneous administration of neuromedin B-10 and gastrin-releasing peptide(1-27) reproduces the satiating and microstructural effects of bombesin

被引：14

作者：

Stratford, TR ^{[1
]}

Gibbs, J ^{[1
]}

Smith, GP ^{[1
]}

机构：

[1] CORNELL UNIV, COLL MED, DEPT PSYCHIAT, EDWARD W BOURNE BEHAV RES LAB, WHITE PLAINS, NY 10605 USA

来源：

PEPTIDES | 1996年 / 17卷 / 01期

关键词：

satiety; feeding behavior; microstructure; licking; peptide interaction;

D O I：

10.1016/0196-9781(95)02086-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bombesin (BN) suppresses food intake more than an equimolar dose of neuromedin B-10 (NMB-10) or gastrin-releasing peptide(1-27) [GRP(1-27)]. Because BN is active at both NMB- and GRP-preferring receptors, it is possible that its greater potency is due to the simultaneous activation of both receptor subtypes. This hypothesis was tested by administering a mixture of NMB-10 and GRP(1-27). The results were consistent with our hypothesis: administration of the mixture of NMB-10 and GRP(1-27) produced an inhibition of intake volume and total licks equivalent to that seen after an equimolar dose of BN and resulted in similar changes in the rate and pattern of licking.

引用

页码：107 / 110

页数：4

共 25 条

[1] POSSIBLE MEDIATION BY LUMINAL SOMATOSTATIN OF BOMBESIN-INDUCED SATIETY IN THE CAT [J].

BADO, A ;

MOIZO, L ;

LAIGNEAU, JP ;

GAUTHIER, M ;

DUBRASQUET, M ;

LEWIN, MJM .

AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 263 (01) :R84-R88

[2] EFFECTS OF BOMBESIN ON FOOD-INTAKE AND GASTRIC-ACID SECRETION IN CATS [J].

BADO, A ;

LEWIN, MJM ;

DUBRASQUET, M .

AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 256 (01) :R181-R186

[3] 2 DISTINCT RECEPTOR SUBTYPES FOR MAMMALIAN BOMBESIN-LIKE PEPTIDES [J].

BATTEY, J ;

WADA, E .

TRENDS IN NEUROSCIENCES, 1991, 14 (12) :524-528

[4] ANALYSIS OF THE MICROSTRUCTURE OF THE RHYTHMIC TONGUE MOVEMENTS OF RATS INGESTING MALTOSE AND SUCROSE SOLUTIONS [J].

DAVIS, JD ;

SMITH, GP .

BEHAVIORAL NEUROSCIENCE, 1992, 106 (01) :217-228

[5]

DAVIS JD, 1989, ANN NY ACAD SCI, V575, P106

[6] CENTRALLY AND PERIPHERALLY ADMINISTERED BOMBESIN DECREASES FOOD-INTAKE IN TURKEYS [J].

DENBOW, DM .

PEPTIDES, 1989, 10 (02) :275-279

[7] EFFECTS OF PERIPHERAL AND CENTRAL BOMBESIN ON FEEDING-BEHAVIOR OF RATS [J].

GIBBS, J ;

KULKOSKY, PJ ;

SMITH, GP .

PEPTIDES, 1981, 2 :179-183

[8] BOMBESIN SUPPRESSES FEEDING IN RATS [J].

GIBBS, J ;

FAUSER, DJ ;

ROWE, EA ;

ROLLS, BJ ;

ROLLS, ET ;

MADDISON, SP .

NATURE, 1979, 282 (5735) :208-210

[9] DISTRIBUTION OF BOMBESIN-LIKE PEPTIDES IN THE ALIMENTARY CANAL OF SEVERAL VERTEBRATE SPECIES [J].

GREELEY, GH ;

PARTIN, M ;

SPANNAGEL, A ;

DINH, T ;

HILL, FLC ;

TROWBRIDGE, J ;

SALTER, M ;

CHUO, HF ;

THOMPSON, JC .

REGULATORY PEPTIDES, 1986, 16 (02) :169-181

[10] BOMBESIN ACTS TO SUPPRESS FEEDING-BEHAVIOR AND ALTER SERUM GROWTH-HORMONE IN GOLDFISH [J].

HIMICK, BA ;

PETER, RE .

PHYSIOLOGY & BEHAVIOR, 1994, 55 (01) :65-72

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