A Tunable Scaffold of Microtubular Graphite for 3D Cell Growth

被引：23

作者：

Lamprecht, Constanze ^{[1
,4
]}

Taale, Mohammadreza ^{[1
]}

Paulowicz, Ingo ^{[1
]}

Westerhaus, Hannes ^{[1
]}

Grabosch, Carsten ^{[1
]}

Schuchardt, Arnim ^{[1
]}

Mecklenburg, Matthias ^{[2
]}

Boettner, Martina ^{[3
]}

Lucius, Ralph ^{[3
]}

Schulte, Karl ^{[2
]}

Adelung, Rainer ^{[1
]}

Selhuber-Unkel, Christine ^{[1
]}

机构：

[1] Univ Kiel, Inst Mat Sci, D-24143 Kiel, Germany

[2] Hamburg Univ Technol, Inst Polymers & Composites, D-21073 Hamburg, Germany

[3] Univ Kiel, Inst Anat, Olshaussenstr 40, D-24118 Kiel, Germany

[4] Johannes Kepler Univ Linz, Inst Biophys, A-4020 Linz, Austria

来源：

ACS APPLIED MATERIALS & INTERFACES | 2016年 / 8卷 / 24期

基金：

欧洲研究理事会;

关键词：

aerographite; tissue engineering; 3D scaffold; cyclic RGD; fibroblasts; POLY(ETHYLENE GLYCOL); DRUG-DELIVERY; BIOMATERIALS; FABRICATION; NETWORKS; MICROENVIRONMENTS; ADHESION;

D O I：

10.1021/acsami.6b00778

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Aerographite (AG) is a novel carbon-based material that exists as a self-supportive 3D network of interconnected hollow microtubules. It can be synthesized in a variety of architectures tailored by the growth conditions. This flexibility in creating structures presents interesting bioengineering possibilities such as the generation of an artificial extracellular matrix. Here we have explored the feasibility and potential of AG as a scaffold for 3D cell growth employing cyclic RGD (cRGD) peptides coupled to poly(ethylene glycol) (PEG) conjugated phospholipids for surface functionalization to promote specific adhesion of fibroblast cells. Successful growth and invasion of the bulk material was followed over a period of 4 days.

引用

页码：14980 / 14985

页数：6

共 32 条

[21] De novo reconstitution of a functional mammalian urinary bladder by tissue engineering [J].