Linking cancer-induced Nlrp3 inflammasome activation to efficient NK cell-mediated immunosurveillance

被引：23
|
作者：
Dagenais, Maryse [1 ]
Saleh, Maya [1 ,2 ,3 ]
机构：
[1] McGill Univ, Dept Biochem, Montreal, PQ, Canada
[2] McGill Univ, Dept Med, Montreal, PQ, Canada
[3] McGill Univ, Dept Microbiol & Immunol, Montreal, PQ, Canada
来源：
ONCOIMMUNOLOGY | 2016年 / 5卷 / 05期
关键词：
Apoptosis; cancer; Fas; immunosurveillance; immunotherapy; innate immunity; NK cells; Nlrp3; inflammasome; COLORECTAL-CANCER; GROWTH;
D O I：
10.1080/2162402X.2015.1129484
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We have recently demonstrated that the Nlrp3 inflammasome can detect the presence of colorectal cancer (CRC) metastatic growth in the liver and limit its growth. Inflammasome signaling primed natural killer (NK) cells through Interleukin (IL)-18 and activated their ability to trigger FasL-induced apoptosis of the tumor.
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页数：3
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