Development of Fecal Microbiota Transplantation Suitable for Mainstream Medicine

被引：38

作者：

Khoruts, Alexander ^{[1
,2
]}

Sadowsky, Michael J. ^{[2
,3
]}

Hamilton, Matthew J. ^{[2
]}

机构：

[1] Univ Minnesota, Ctr Immunol, Dept Med, Div Gastroenterol, Minneapolis, MN 55414 USA

[2] Univ Minnesota, Inst Biotechnol, Minneapolis, MN 55414 USA

[3] Univ Minnesota, Microbial & Plant Genom Inst, Dept Soil Water & Climate, Minneapolis, MN 55414 USA

来源：

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY | 2015年 / 13卷 / 02期

关键词：

Microbiota; Fecal Transplant; Microbiome; Clostridium difficile infection; CLOSTRIDIUM-DIFFICILE INFECTION; DIAGNOSIS; GUT;

D O I：

10.1016/j.cgh.2014.11.014

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Fecal microbiota transplantation has emerged as an increasingly common treatment for patients with refractory Clostridium difficile infection. Although it can be relatively simple to perform, a number of challenges need to be overcome before this procedure is widely accepted in mainstream clinical practice. Most of the solutions to these challenges already exist, but some need further optimization and testing. Standardized fecal microbiota is being developed as a therapeutic agent, although it clearly challenges some of the existing paradigms of drug development, delivery, and regulation.

引用

收藏

页码：246 / 250

页数：5

相关论文

共 26 条

[1] Fecal microbiota transplantation: past, present and future [J].

Aroniadis, Olga C. ;

Brandt, Lawrence J. .

CURRENT OPINION IN GASTROENTEROLOGY, 2013, 29 (01) :79-84

[2] Host-bacterial mutualism in the human intestine [J].

Bäckhed, F ;

Ley, RE ;

Sonnenburg, JL ;

Peterson, DA ;

Gordon, JI .

SCIENCE, 2005, 307 (5717) :1915-1920

[3] Treating Clostridium difficile Infection With Fecal Microbiota Transplantation [J].

Bakken, Johan S. ;

Borody, Thomas ;

Brandt, Lawrence J. ;

Brill, Joel V. ;

Demarco, Daniel C. ;

Franzos, Marc Alaric ;

Kelly, Colleen ;

Khoruts, Alexander ;

Louie, Thomas ;

Martinelli, Lawrence P. ;

Moore, Thomas A. ;

Russell, George ;

Surawicz, Christina .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2011, 9 (12) :1044-1049

[4]

Buffie CG, 2014, NATURE

[5] Diet rapidly and reproducibly alters the human gut microbiome [J].

David, Lawrence A. ;

Maurice, Corinne F. ;

Carmody, Rachel N. ;

Gootenberg, David B. ;

Button, Julie E. ;

Wolfe, Benjamin E. ;

Ling, Alisha V. ;

Devlin, A. Sloan ;

Varma, Yug ;

Fischbach, Michael A. ;

Biddinger, Sudha B. ;

Dutton, Rachel J. ;

Turnbaugh, Peter J. .

NATURE, 2014, 505 (7484) :559-+

[6] Reset of a critically disturbed microbial ecosystem: faecal transplant in recurrent Clostridium difficile infection [J].

Fuentes, Susana ;

van Nood, Els ;

Tims, Sebastian ;

Heikamp-de Jong, Ineke ;

ter Braak, Cajo J. F. ;

Keller, Josbert J. ;

Zoetendal, Erwin G. ;

de Vos, Willem M. .

ISME JOURNAL, 2014, 8 (08) :1621-1633

[7] Systematic Review of Intestinal Microbiota Transplantation (Fecal Bacteriotherapy) for Recurrent Clostridium difficile Infection [J].

Gough, Ethan ;

Shaikh, Henna ;

Manges, Amee R. .

CLINICAL INFECTIOUS DISEASES, 2011, 53 (10) :994-1002

[8] New molecular approaches in the diagnosis of acute diarrhea: advantages for clinicians and researchers [J].

Guarino, Alfredo ;

Giannattasio, Antonietta .

CURRENT OPINION IN GASTROENTEROLOGY, 2011, 27 (01) :24-29

[9] High-throughput DNA sequence analysis reveals stable engraftment of gut microbiota following transplantation of previously frozen fecal bacteria [J].

Hamilton, Matthew J. ;

Weingarden, Alexa R. ;

Unno, Tatsuya ;

Khoruts, Alexander ;

Sadowsky, Michael J. .

GUT MICROBES, 2013, 4 (02) :125-135

[10] Standardized Frozen Preparation for Transplantation of Fecal Microbiota for Recurrent Clostridium difficile Infection [J].

Hamilton, Matthew J. ;

Weingarden, Alexa R. ;

Sadowsky, Michael J. ;

Khoruts, Alexander .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2012, 107 (05) :761-767