Metabolism of glycyrrhizin and baicalin by human intestinal bacteria

被引：19

作者：

Kim, DH

Jang, IS

Lee, HK

Jung, EA

Lee, KY

机构：

[1] KYUNG HEE UNIV,COLL PHARM,DONGDAEMUN KU,SEOUL 130701,SOUTH KOREA

[2] KOREAN RES INST BIOSCI & BIOTECHNOL,TAEJON 350600,SOUTH KOREA

来源：

ARCHIVES OF PHARMACAL RESEARCH | 1996年 / 19卷 / 04期

关键词：

glycyrrhizin; intestinal bacteria; baicalin; Bacteroides J-37;

D O I：

10.1007/BF02976243

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

By human intestinal bacteria, glycyrrhizin (18 beta-glycyrrhetic acid beta-D-glucuronyl alpha-D-glucuronic acid, GL) and baicalin (baicalein beta-D-glucuronic acid) were metabolized to glycyrrhetinic acid and baicalin, respectively. However, cr-glucuronidase of Bacteroides JY-6 isolated from human intestinal bacteria hydrolyzed GL or 18 beta-glycyrrhetinic acid alpha-D-glucuronic acid to 18 beta-glycyrrhetic acid but did not baicalin. However, E. coli beta-glucuronidase from human intestinal bacteria hydrolyzed baicalin to baicalein, but did not GL, beta-Glucuronidase of mammalian tissues hydrolyzed both GL and baicalin.

引用

页码：292 / 296

页数：5

共 11 条

[1] INTERFERON INDUCTION BY GLYCYRRHIZIN AND GLYCYRRHETINIC ACID IN MICE [J].