The Development of FtsZ Inhibitors as Potential Antibacterial Agents

被引：50
作者：
Ma, Siti [1 ]
Ma, Shutao [1 ]
机构：
[1] Shandong Univ, Dept Med Chem, Key Lab Chem Biol, Minist Educ,Sch Pharmaceut Sci, Jinan 250012, Peoples R China
来源：
CHEMMEDCHEM | 2012年 / 7卷 / 07期
基金：
中国国家自然科学基金;
关键词：
biological activity; FtsZ; inhibitors; mechanisms of action; synthetic methods; BACTERIAL-CELL-DIVISION; PRODUCTS TARGETING FTSZ; PROTEIN FTSZ; MYCOBACTERIUM-TUBERCULOSIS; ASSEMBLY DYNAMICS; FLUORESCENT-PROBE; CRYSTAL-STRUCTURE; SMALL-MOLECULE; IN-VITRO; TUBULIN;
D O I：
10.1002/cmdc.201200156
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The emergence and prevalence of bacterial resistance has resulted in a clear demand for novel antibacterial drugs. As a tubulin homologue, FtsZ is an essential cell-division protein in prokaryotic organisms and is showing increasing promise as a target for antibacterial drug discovery. This review describes the role of FtsZ in bacterial cytokinesis and various FtsZ inhibitors, with particular focus on their discovery, antibacterial activities, mechanisms of action, synthetic methods, and representative analogues.
引用
收藏
页码：1161 / 1172
页数：12
相关论文
共 115 条
[51]   GTP analogue inhibits polymerization and GTPase activity of the bacterial protein FtsZ without affecting its eukaryotic homologue tubulin [J].
Läppchen, T ;
Hartog, AF ;
Pinas, VA ;
Koomen, GJ ;
den Blaauwen, T .
BIOCHEMISTRY, 2005, 44 (21) :7879-7884
[52]   Structure of Mycobacterium tuberculosis FtsZ reveals unexpected, G protein-like conformational switches [J].
Leung, AKW ;
White, EL ;
Ross, LJ ;
Reynolds, RC ;
DeVito, JA ;
Borhani, DW .
JOURNAL OF MOLECULAR BIOLOGY, 2004, 342 (03) :953-970
[53]   Cell-division inhibitors: new insights for future antibiotics [J].
Lock, Rowena L. ;
Harry, Elizabeth J. .
NATURE REVIEWS DRUG DISCOVERY, 2008, 7 (04) :324-338
[54]   Crystal structure of the bacterial cell-division protein FtsZ [J].
Löwe, J ;
Amos, LA .
NATURE, 1998, 391 (6663) :203-206
[55]   Tubulin-like protofilaments in Ca2+-induced FtsZ sheets [J].
Löwe, J ;
Amos, LA .
EMBO JOURNAL, 1999, 18 (09) :2364-2371
[56]   Straight and curved conformations of FtsZ are regulated by GTP hydrolysis [J].
Lu, CL ;
Reedy, M ;
Erickson, HP .
JOURNAL OF BACTERIOLOGY, 2000, 182 (01) :164-170
[57]   Molecular insights into aminoglycoside action and resistance [J].
Magnet, S ;
Blanchard, JS .
CHEMICAL REVIEWS, 2005, 105 (02) :477-497
[58]   In vitro susceptibility of Helicobacter pylori to isoquinoline alkaloids from sanguinaria canadensis and Hydrastis canadensis [J].
Mahady, GB ;
Pendland, SL ;
Stoia, A ;
Chadwick, LR .
PHYTOTHERAPY RESEARCH, 2003, 17 (03) :217-221
[59]   Targeting cell division: Small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality [J].
Margalit, DN ;
Romberg, L ;
Mets, RB ;
Hebert, AM ;
Mitchison, TJ ;
Kirschner, MW ;
RayChaudhuri, D .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (32) :11821-11826
[60]  
Mayer M, 1999, ANGEW CHEM INT EDIT, V38, P1784, DOI 10.1002/(SICI)1521-3773(19990614)38:12<1784::AID-ANIE1784>3.0.CO
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