K, Ca complexes with a sulfonic ligand: Structure and DNA-binding properties

被引：2

作者：

Luo, Jiahe ^{[3
]}

Ma, Zhaorong ^{[1
,2
]}

Liang, Huang ^{[1
,2
]}

Chen, Jiwen ^{[3
]}

Zeng, Zhengzhi ^{[1
,2
]}

机构：

[1] Lanzhou Univ, Key Lab Nonferrous Met Chem & Resources Utilizat, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

[2] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China

[3] Guangdong Testing Inst Product Qual Supervis, Natl Qual Supervis & Test Ctr Paints, Guangzhou, Guangdong, Peoples R China

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2012年 / 90卷

关键词：

(E)-4-(2,4-dihydroxybenzylideneamino)benzenesulfonic acid; K and Ca complexes; Crystal structure; DNA binding; Photocleavage; CRYSTAL-STRUCTURE; ACID; TRIS(PHENANTHROLINE)RUTHENIUM(II); BENZOTHIAZOLE-2-THIOLATE; IDENTIFICATION; CLEAVAGE; CHANNELS; PROBE;

D O I：

10.1016/j.saa.2012.01.035

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

A novel 4-(2,4-dihydroxybenzylideneamino)benzenesulfonic acid (HL), and its kalium(I), calcium(II) complexes [M(L)n]center dot 2nH(2)O center dot Cl-n (M = K(1) n = 1, M = Ca(2) n =2), have been prepared and characterized. The crystal and molecular structures of 1 and 2 were determined by single-crystal X-ray diffraction. The interaction of 1,2 and ligand (L) with calf thymus DNA was investigated by UV-visible (UV-vis), fluorescence and viscosity measurements. Experimental results indicate that 1, 2 and L could bind to DNA via the intercalation mode, and the binding affinity of 1 is stronger than that of 2 and L. The intrinsic binding constants of 1,2 and L were 5.60 X 10(5), 6.53 x 10(5) and 1.44 x 10(5) M-1, respectively. The cleavage reaction on plasmid DNA has been monitored by agarose gel electrophoresis. The results indicated that 1 and 2 could cleave pBR322 DNA. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：202 / 207

页数：6

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