Intermolecular Ritter-Type C-H Amination of Unactivated sp3 Carbons

被引：224

作者：

Michaudel, Quentin ^{[1
]}

Thevenet, Damien ^{[1
]}

Baran, Phil S. ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 05期

基金：

瑞士国家科学基金会;

关键词：

CATALYZED AZIRIDINATION; BONDS; COMPLEXES; INSERTION; FUNCTIONALIZATION; FLUORINATION; SELECTFLUOR; DERIVATIVES; CONVERSION; AMIDATION;

D O I：

10.1021/ja212020b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Intermolecular Ritter-type C-H amination of unactivated sp(3) carbons has been developed. This new reaction proceeds under mild conditions using readily available reagents and an inexpensive source of nitrogen (acetonitrile). A broad scope of substrates can be aminated with this method since many functional groups are tolerated. This reaction also allows for the direct, innate C H amination of a variety of hydrocarbons such as cyclohexane without the need of prefunctionalization or installation of a directing group.

引用

页码：2547 / 2550

页数：4

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