Targeting Voltage-Gated Sodium Channels for Treating Neuropathic and Inflammatory Pain

被引：0
作者：
Cohen, Charles J. [1 ]
机构：
[1] Xenon Pharmaceut, Burnaby, BC V5G 4W8, Canada
来源：
CURRENT PHARMACEUTICAL BIOTECHNOLOGY | 2011年 / 12卷 / 10期
关键词：
Analgesia; Na-V; pain; voltage-gated sodium channel; RAT HIPPOCAMPAL-NEURONS; LOCAL-ANESTHETICS; SYSTEMIC LIDOCAINE; NERVE INJURY; INTRAVENOUS LIDOCAINE; ION CHANNELS; MOUSE MODEL; ALLODYNIA; EPILEPSY; CONDUCTION;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Voltage-gated sodium channels (Na-V) are well validated targets for treating pain based both on human genetics and clinical experience. Consequently, there is an extensive literature on sodium channels for the treatment of pain and a number of excellent and thorough reviews have recently appeared; a selection of these is provided. This review does not attempt to evaluate all aspects of the studies in this area, but rather will focuses on several key issues that are incompletely addressed in prior reviews or that represent very recent additions to the literature. Key questions that arise are: 1) How much channel block is required to observe efficacy against neuropathic or inflammatory pain? 2) How can one improve upon the therapeutic index of previously tested NaV blockers?
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页码：1715 / 1719
页数：5
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