The Effect of Resveratrol on Cell Viability in the Burkitt's Lymphoma Cell Line Ramos

被引：20

作者：

Jara, Paola ^{[1
]}

Spies, Johana ^{[1
]}

Carcamo, Constanza ^{[1
]}

Arancibia, Yennyfer ^{[1
]}

Vargas, Gabriela ^{[1
]}

Martin, Carolina ^{[2
]}

Salas, Monica ^{[1
]}

Otth, Carola ^{[3
,4
]}

Zambrano, Angara ^{[1
,4
]}

机构：

[1] Univ Austral Chile, Fac Ciencias, Inst Bioquim & Microbiol, Valdivia 5090000, Chile

[2] Univ Austral Chile, Escuela Tecnol Med, Sede Puerto Montt 5480000, Chile

[3] Univ Austral Chile, Fac Med, Inst Microbiol Clin, Valdivia 5090000, Chile

[4] Univ Austral Chile, Ctr Interdisciplinary Studies Nervous Syst CISNe, Valdivia 5090000, Chile

来源：

MOLECULES | 2018年 / 23卷 / 01期

关键词：

resveratrol; cell viability; Ramos cells; DNA damage; DNA repair; DOUBLE-STRAND BREAKS; B-CELL; INDUCED APOPTOSIS; GERMINAL CENTER; CANCER CELLS; GENOTOXIC STRESS; TOPOISOMERASE-II; LEUKEMIA CELLS; IN-VITRO; INHIBITION;

D O I：

10.3390/molecules23010014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Resveratrol is a polyphenolic natural compound produced by a variety of crops. Currently, resveratrol is considered a multi-target anti-cancer agent with pleiotropic activity, including the ability to prevent the proliferation of malignant cells by inhibiting angiogenesis and curtailing invasive and metastatic factors in many cancer models. However, the molecular mechanisms mediating resveratrol-specific effects on lymphoma cells remain unknown. To begin tackling this question, we treated the Burkitt's lymphoma cell line Ramos with resveratrol and assessed cell survival and gene expression. Our results suggest that resveratrol shows a significant anti-proliferative and pro-apoptotic activity on Ramos cells, inducing the DNA damage response, DNA repairing, and modulating the expression of several genes that regulate the apoptotic process and their proliferative activity.

引用

页数：12

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