PTX3, A HUMORAL PATTERN RECOGNITION MOLECULE, IN INNATE IMMUNITY, TISSUE REPAIR, AND CANCER

被引：180

作者：

Garlanda, Cecilia ^{[1
,2
]}

Bottazzi, Barbara ^{[1
]}

Magrini, Elena ^{[1
]}

Inforzato, Antonio ^{[1
,3
]}

Mantovani, Alberto ^{[1
,2
,4
]}

机构：

[1] Humanitas Clin & Res Ctr, Milan, Italy

[2] Humanitas Univ, Milan, Italy

[3] Univ Milan, Dept Med Biotechnol & Translat Med, Milan, Italy

[4] Queen Mary Univ London, William Harvey Res Inst, Charterhouse Sq, London EC1M 6BQ, England

来源：

PHYSIOLOGICAL REVIEWS | 2018年 / 98卷 / 02期

基金：

欧洲研究理事会;

关键词：

LONG PENTRAXIN PTX3; C-REACTIVE PROTEIN; COMPLEMENT FACTOR-H; INFLUENZA-A VIRUSES; CARDIOVASCULAR-DISEASE; PLASMA-LEVELS; EXTRACELLULAR-MATRIX; GENETIC-VARIATION; RECEPTOR PTX3; FUNCTIONAL-CHARACTERIZATION;

D O I：

10.1152/physrev.00016.2017

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Innate immunity includes a cellular and a humoral arm. PTX3 is a fluid-phase pattern recognition molecule conserved in evolution which acts as a key component of humoral innate immunity in infections of fungal, bacterial, and viral origin. PTX3 binds conserved microbial structures and self-components under conditions of inflammation and activates effector functions (complement, phagocytosis). Moreover, it has a complex regulatory role in inflammation, such as ischemia/reperfusion injury and cancer-related inflammation, as well as in extracellular matrix organization and remodeling, with profound implications in physiology and pathology. Finally, PTX3 acts as an extrinsic oncosuppressor gene by taming tumor-promoting inflammation in murine and selected human tumors. Thus evidence suggests that PTX3 is a key homeostatic component at the crossroad of innate immunity, inflammation, tissue repair, and cancer. Dissecting the complexity of PTX3 pathophysiology and human genetics paves the way to diagnostic and therapeutic exploitation.

引用

收藏

页码：623 / 639

页数：17

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