c-Cbl targets active Src for autophagy

被引：15

作者：

Cecconi, Francesco ^{[1
,2
]}

机构：

[1] Univ Roma Tor Vergata, Dept Biol, Dulbecco Telethon Inst, I-00133 Rome, Italy

[2] IRCCS Santa Lucia Fdn, I-00143 Rome, Italy

来源：

NATURE CELL BIOLOGY | 2012年 / 14卷 / 01期

关键词：

TUMOR DORMANCY; CELL-SURVIVAL; CANCER; PHOSPHORYLATION; UBIQUITINATION; DEGRADATION; SENESCENCE; RESTRICTS;

D O I：

10.1038/ncb2413

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Autophagy can promote both cancer cell survival and death, and the mechanisms by which it mediates these disparate processes are under intense investigation. Autophagosomes are now shown to entrap and promote degradation of the active tyrosine kinase Src, enabling tumour cell survival. The E3 ubiquitin ligase c-Cbl acts as an autophagosome cargo receptor for Src.

引用

页码：48 / 49

页数：2

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