NOD2/CARD15 gene polymorphisms affect outcome in pediatric allogeneic stem cell transplantation

被引：7

作者：

Kreyenberg, Hermann ^{[1
]}

Jarisch, Andrea ^{[1
]}

Bayer, Christina ^{[1
]}

Schuster, Blanca ^{[1
]}

Willasch, Andre ^{[1
]}

Strahm, Brigitte ^{[2
]}

Kremens, Bernhard ^{[3
]}

Gruhn, Bernd ^{[4
]}

Schrauder, Andre ^{[5
,6
]}

Burdach, Stefan ^{[7
,8
]}

Fuehrer, Monika ^{[9
]}

Rossig, Claudia ^{[10
]}

Kabisch, Hartmut ^{[11
]}

Schlegel, Paul-Gerhard ^{[12
]}

Stachel, Daniel ^{[13
]}

Beck, James F. ^{[14
]}

Mauz-Koerholz, Christine ^{[15
]}

Chung, Tje Lin ^{[16
]}

Holler, Ernst ^{[17
]}

Klingebiel, Thomas ^{[1
]}

Bader, Peter ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, Hosp Children & Adolescents, Frankfurt, Germany

[2] Univ Freiburg, Dept Pediat & Adolescent Med, Freiburg, Germany

[3] Univ Essen Gesamthsch, Childrens Hosp, Dept Pediat Hematol & Oncol, Essen, Germany

[4] Univ Jena, Dept Pediat, Jena, Germany

[5] Univ Schleswig Holstein, Dept Pediat, Kiel, Germany

[6] Univ Schleswig Holstein, BMT Unit, Kiel, Germany

[7] Tech Univ Munich, Dept Pediat, Munich, Germany

[8] Tech Univ Munich, POC, Munich, Germany

[9] Univ Munich, Dr von Haunersches Childrens Hosp, Munich, Germany

[10] Univ Childrens Hosp Muenster, Dept Pediat Hematol & Oncol, Munster, Germany

[11] Univ Med Ctr Hamburg Eppendorf, Dept Pediat Hematol & Oncol, Hamburg, Germany

[12] Julius Maximilian Univ Childrens Hosp, Dept Pediat Hematol & Oncol, Wurzburg, Germany

[13] Univ Erlangen Nurnberg, Univ Childrens Hosp, Dept Pediat Hematol & Oncol, Erlangen, Germany

[14] Univ Childrens Hosp Greifswald, Dept Pediat Hematol & Oncol, Greifswald, Germany

[15] Univ Halle Wittenberg, Clin & Polyclin Child & Adolescent Med, Halle, Saale, Germany

[16] Goethe Univ Frankfurt, Inst Biostat & Math Modeling, Frankfurt, Germany

[17] Univ Med Ctr, Dept Haematol Oncol, Regensburg, Germany

来源：

BLOOD | 2011年 / 118卷 / 04期

关键词：

GRAFT-VERSUS-HOST; DISEASE; MUTATIONS; MORTALITY; DONOR; NOD2; RISK;

D O I：

10.1182/blood-2011-05-356451

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：1181 / 1184

页数：6

共 10 条

[1] Mutations in innate immune system NOD2/CARD 15 and TLR-4 (Thr399Ile) genes influence the risk for severe acute graft-versus-host disease in patients who underwent an allogeneic transplantation [J].

Elmaagacli, AH ;

Koldehoff, M ;

Hindahl, H ;

Steckel, NK ;

Trenschel, R ;

Peceny, R ;

Ottinger, H ;

Rath, PM ;

Ross, RS ;

Roggendorf, M ;

Grosse-Wilde, H ;

Beelen, DW .

TRANSPLANTATION, 2006, 81 (02) :247-254

[2]

Granell M, 2006, HAEMATOLOGICA, V91, P1372

[3] Polymorphism of Interleukin-23 Receptor Gene But Not of NOD2/CARD15 Is Associated with Graft-versus-Host Disease after Hematopoietic Stem Cell Transplantation in Children [J].

Gruhn, Bernd ;

Intek, Juliane ;

Pfaffendorf, Nadine ;

Zell, Roland ;

Corbacioglu, Selim ;

Zintl, Felix ;

Beck, James F. ;

Debatin, Klaus-Michael ;

Steinbach, Daniel .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2009, 15 (12) :1571-1577

[4] Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation [J].

Holler, E ;

Rogler, G ;

Herfarth, H ;

Brenmoehl, J ;

Wild, PJ ;

Hahn, J ;

Eissner, G ;

Schölmerich, J ;

Andreesen, R .

BLOOD, 2004, 104 (03) :889-894

[5] Single nucleotide Polymorphisms in the NOD2/CARD15 gene are associated with an increased risk of relapse and death for patients with acute leukemia after hematopoietic stem-cell transplantation with unrelated donors [J].

Mayor, Neema P. ;

Shaw, Bronwen E. ;

Hughes, Derralynn A. ;

Maldonado-Torres, Hazael ;

Madrigal, J. Alejandro ;

Keshav, Satish ;

Marsh, Steven G. E. .

JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (27) :4262-4269

[6] Insufficient evidence for association of NOD2/CARD15 or other inflammatory bowel disease-associated markers on GVHD incidence or other adverse outcomes in T-replete, unrelated donor transplantation [J].

Nguyen, Yume ;

Al-Lehibi, Abed ;

Gorbe, Elizabeth ;

Li, Ellen ;

Haagenson, Michael ;

Wang, Tao ;

Spellman, Stephen ;

Lee, Stephanie J. ;

Davidson, Nicholas O. .

BLOOD, 2010, 115 (17) :3625-3631

[7] No impact of NOD2/CARD15 on outcome after SCT [J].

Sairafi, D. ;

Uzunel, M. ;

Remberger, M. ;

Ringden, O. ;

Mattsson, J. .

BONE MARROW TRANSPLANTATION, 2008, 41 (11) :961-964

[8] NOD2/CARD15 Variants Are Not a Risk Factor for Clinical Outcome after Nonmyeloablative Allogeneic Stem Cell Transplantation [J].

van der Straaten, Hanneke M. ;

Paquay, Martine M. ;

Tilanus, Marcel G. J. ;

van Geloven, Nan ;

Verdonck, Leo F. ;

Huisman, Cynthia .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2011, 17 (08) :1231-1236

[9] NOD2 polymorphisms predict severe acute graft-versus-host and treatment-related mortality in T-cell-depleted haematopoietic stem cell transplantation [J].

van der Velden, W. J. F. M. ;

Blijlevens, N. M. A. ;

Maas, F. M. H. M. ;

Schaap, N. P. M. ;

Jansen, J. H. ;

van der Reijden, B. A. ;

Feuth, T. ;

Dolstra, H. ;

Donnelly, J. P. .

BONE MARROW TRANSPLANTATION, 2009, 44 (04) :243-248

[10] Genetic Variations of Interleukin-23R (1143A>G) and BPI (A645G), but Not of NOD2, Are Associated with Acute Graft-versus-Host Disease after Allogeneic Transplantation [J].

Wermke, Martin ;

Maiwald, Stefanie ;

Schmelz, Renate ;

Thiede, Christian ;

Schetelig, Johannes ;

Ehninger, Gerhard ;

Bornhauser, Martin ;

Wassmuth, Ralf .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2010, 16 (12) :1718-1727

← 1 →