Reversal of CSF positivity for JC virus genome by cidofovir in a patient with systemic lupus erythematosus and progressive multifocal leukoencephalopathy

被引：24

作者：

Salmaggi, A

Maccagnano, E

Castagna, A

Zeni, S

Fantini, F

Cinque, P

Savoiardo, M

机构：

[1] Natl Neurol Inst C Besta, I-20133 Milan, Italy

[2] Gaetano Pini Orthoped Inst, Milan, Italy

[3] Univ Milan, Osped San Raffaele, IRCCS, I-20127 Milan, Italy

来源：

NEUROLOGICAL SCIENCES | 2001年 / 22卷 / 01期

关键词：

SLE; PML; JC virus genome; cerebrospinal fluid; cidofovir;

D O I：

10.1007/s100720170031

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report the case of a 36-year-old woman affected by systemic lupus erythematosus who developed rapidly progressive multifocal leukoencephalopathy. Cidofovir therapy induced disappearance of JC virus genome from the cerebrospinal fluid and stabilization of the MRI picture. Despite the fatal outcome after a few months of disease, cidofovir treatment deserves further testing as single antiviral therapy in HIV-negative PML patients.

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页码：17 / 20

页数：4

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