Principles of protein-protein interactions: What are the preferred ways for proteins to interact?

被引：521

作者：

Keskin, Ozlem ^{[1
,2
,4
]}

Gursoy, Attila ^{[1
,2
]}

Ma, Buyong

Nussinov, Ruth ^{[3
,4
]}

机构：

[1] Koc Univ, Ctr Computat Biol & Bioinformat, TR-34450 Istanbul, Turkey

[2] Koc Univ, Coll Engn, TR-34450 Istanbul, Turkey

[3] Tel Aviv Univ, Sackler Sch Med, Sackler Inst Mol Med, Dept Human Genet & Mol Med, IL-69978 Tel Aviv, Israel

[4] NCI, SAIC Frederick Inc, Ctr Canc Res Nanobiol Program, Basic Res Program, Frederick, MD 21702 USA

来源：

CHEMICAL REVIEWS | 2008年 / 108卷 / 04期

关键词：

D O I：

10.1021/cr040409x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The main reason for the increased interest in protein-protein interactions are the better quantization of the key features controlling the interactions which will lead to higher success in the prediction of protein associations. Such an analysis will focus on protein surfaces. Meanwhile, it is important to have the structures of the proteins to identify the residues and atom groups that line the protein surface. The determination of which residues and atoms are on the surface is usually carried out through calculations of the surface area that is accessible to the solvent.

引用

页码：1225 / 1244

页数：20

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